endosergЭндокринная хирургияEndocrine Surgery2306-35132310-3965Типография «Печатных дел Мастер»10.14341/serg10039endoserg-10039Research ArticleОбзоры литературыReview of literatureОколощитовидные железы: нормальное развитие, анатомическое и гистологическое строениеParathyroid glands: the normal development, anatomy and histological structurehttps://orcid.org/0000-0002-9717-9742МокрышеваНаталья ГеоргиевнаMokryshevaNatalia G.

д.м.н., профессор

MD, PhD, Professor

nm70@mail.ruhttps://orcid.org/0000-0001-7963-5022КрупиноваЮлия АлександровнаKrupinovaJulia A.

MD

j.krupinova@gmail.comhttps://orcid.org/0000-0001-6687-3240ВоронковаИя АлександровнаVoronkovaIya A.

к.м.н.

MD, PhD

iya-v@yandex.ru<p>ФГБУ &ldquo;Национальный медицинский исследовательский центр эндокринологии&rdquo; Минздрава России</p>Россия<p>Endocrinology Research Centre</p>Russian Federation<p>ФГБУ &ldquo;Национальный медицинский исследовательский центр эндокринологии&rdquo; Минздрава России; ГБУЗ МО &ldquo;Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского&rdquo;</p>Россия<p>Endocrinology Research Centre; M.F. Vladimirskiy Moscow Regional Research Clinical Institute</p>Russian Federation201821052019124178187Copyright &#x00A9; Мокрышева Н.Г., Крупинова Ю.А., Воронкова И.А., 20182018Мокрышева Н.Г., Крупинова Ю.А., Воронкова И.А.Mokrysheva N.G., Krupinova J.A., Voronkova I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surg-endojournals.ru/jour/article/view/10039

Околощитовидные железы (ОЩЖ) – ключевые регуляторы обмена кальция и фосфора в организме. Впервые они были описаны англичанином Ричардом Оуэном в 1849 г. В большинстве случаев у человека две пары ОЩЖ – верхняя и нижняя. В 13% случаев встречается более четырех ОЩЖ. Железы развиваются между пятой и двенадцатой неделями гестации из клеточного материала выстилки глоточных карманов: верхние железы – из IV, нижние – из III кармана. Продукция паратиреоидного гормона начинается на 83/7 неделе гестации. Формирование, миграция, дифференцировка и функционирование ОЩЖ детерминированы рядом генов, изменения в которых могут приводить к дисбалансу этих процессов. При нарушении миграции возможна эктопия ОЩЖ (до 22% случаев), при этом наиболее частыми местами эктопической локализации ОЩЖ являются паренхима тимуса и щитовидной железы. ОЩЖ обладает хорошо развитой сосудистой сетью и окружена тонкой фиброзной капсулой. Паренхима желез представлена в основном двумя типами клеток: главными (активные и неактивные формы) и оксифильными. В течение жизни соотношение типов клеток паренхимы ОЩЖ и их активность меняются, как  и характеристики стромы.

Parathyroid glands (PG) are endocrine glands, which are the most important humoral regulators of calcium and phosphorus metabolism in the body. They were first described by an Englishman Richard Owen in 1849. Most of patients have four PG – upper and lower. In 13% of cases there are more than four PG. The glands arise as diverticula from the endoderm of the third and fourth branchial pouches between the fifth and twelfth week of gestation. The IV branchial pouch forms the upper gland, and III pouch forms the inferior gland.

The parathyroid hormone production has been demonstrated as early as 83/7 weeks gestational age. The formation, migration, differentiation and functioning of the PGs are determined by a number of genes and changes in them could lead to disfunction in these processes. The ectopic of PG is possible when migration violation (up to 22% of cases). The most common location of the ectopic PG is parenchyma of the thymus and thyroid gland. Each PG is richly vascularized and it is surrounded by a thin connective tissue. In adults, there are two types of parenchymal cells: the chief cells (active and inactive forms) and the oxyphil cells. During the life, the ratio of types of parenchymal cells and their activity have been changing, as well as the characteristics of the stroma.

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