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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">endoserg</journal-id><journal-title-group><journal-title xml:lang="ru">Эндокринная хирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Endocrine Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2306-3513</issn><issn pub-type="epub">2310-3965</issn><publisher><publisher-name>Типография «Печатных дел Мастер»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/serg12936</article-id><article-id custom-type="elpub" pub-id-type="custom">endoserg-12936</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзор</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Возможности лапароскопических вмешательств у детей с панкреатическими инсулиномами</article-title><trans-title-group xml:lang="en"><trans-title>Possibilities of laparoscopic interventions in children with pancreatic insulinomas</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3831-768X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколов</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolov</surname><given-names>Yu. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соколов Юрий Юрьевич, д.м.н., профессор</p><p>Москва</p></bio><bio xml:lang="en"><p>Yurii Yu. Sokolov, MD, PhD, Professor</p><p>Moscow</p></bio><email xlink:type="simple">sokolov-surg@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3734-6510</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бровин</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Brovin</surname><given-names>D. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бровин Дмитрий Николаевич, к.м.н. </p><p>Москва</p></bio><bio xml:lang="en"><p>Dmitry N. Brovin, MD, PhD</p><p>Moscow</p></bio><email xlink:type="simple">d.brovin@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5415-0499</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахматов</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhamatov</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахматов Роман Анатольевич, к.м.н. </p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1 </p></bio><bio xml:lang="en"><p>Roman A. Akhamatov, MD, PhD</p><p>2/1 bld. 1, Barrikadnaya str., Moscow, 125993</p></bio><email xlink:type="simple">dr.akhmatov@ped-surgery.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5394-0165</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефременков</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Efremenkov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефременков Артем Михайлович, к.м.н. </p><p>Москва</p></bio><bio xml:lang="en"><p>Artem M. Efremenkov, MD, PhD</p><p>Moscow</p></bio><email xlink:type="simple">efremart@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5462-2388</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солодинина</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Solodinina</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Солодинина Елена Николаевна, д.м.н.</p><p>Москва</p></bio><bio xml:lang="en"><p>Elena N. Solodinina, MD, PhD</p><p>Moscow</p></bio><email xlink:type="simple">solodinina@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5656-1382</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аникиев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Anikiev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аникиев Александр Вячеславович, к.м.н. </p><p>Москва</p></bio><bio xml:lang="en"><p>Alexandr V. Anikiev, MD, PhD</p><p>Moscow</p></bio><email xlink:type="simple">anikieal70@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3551-1970</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зыкин</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Zykin</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зыкин Александр Павлович, к.м.н. </p><p>Москва</p></bio><bio xml:lang="en"><p>Alexandr P. Zykin MD, PhD</p><p>Moscow</p></bio><email xlink:type="simple">Alr-z@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education; Central Clinical Hospital of the Management Affair of President Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Endocrinology Research Centre Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Clinical Hospital of the Management Affair of President Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>13</day><month>03</month><year>2025</year></pub-date><volume>18</volume><issue>4</issue><fpage>4</fpage><lpage>13</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Соколов Ю.Ю., Бровин Д.Н., Ахматов Р.А., Ефременков А.М., Солодинина Е.Н., Аникиев А.В., Зыкин А.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Соколов Ю.Ю., Бровин Д.Н., Ахматов Р.А., Ефременков А.М., Солодинина Е.Н., Аникиев А.В., Зыкин А.П.</copyright-holder><copyright-holder xml:lang="en">Sokolov Y.Y., Brovin D.N., Akhamatov R.A., Efremenkov A.M., Solodinina E.N., Anikiev A.V., Zykin A.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.surg-endojournals.ru/jour/article/view/12936">https://www.surg-endojournals.ru/jour/article/view/12936</self-uri><abstract><sec><title>АКТУАЛЬНОСТЬ</title><p>АКТУАЛЬНОСТЬ. Инсулинома – опухоль β-клеток островков Лангерганса, секретирующая избыточное количество инсулина, что проявляется приступами гипогликемических симптомов. Диагностика локализации инсулином в поджелудочной железе бывает крайне затруднительна и должна включать все доступные методы лучевой диагностики. Единственный радикальный способ лечения инсулином – хирургический. Традиционно данные операции выполнялись в открытом варианте. Имеются только единичные публикации о выполнении лапароскопических вмешательств у детей с инсулиномами.</p></sec><sec><title>ЦЕЛЬ</title><p>ЦЕЛЬ. Представить опыт применения лапароскопических технологий при лечении детей с инсулиномами различных локализаций.</p></sec><sec><title>МАТЕРИАЛЫ И МЕТОДЫ</title><p>МАТЕРИАЛЫ И МЕТОДЫ. В период с 2016 по 2023 гг. по поводу инсулином поджелудочной железы были оперированы 12 девочек в возрасте от 7 до 17 лет. Средний возраст пациентов составил 12,5±3,1 года.</p></sec><sec><title>РЕЗУЛЬТАТЫ</title><p>РЕЗУЛЬТАТЫ. Все операции завершены лапароскопическим доступом. Интраоперационных осложнений не отмечено. В раннем послеоперационном периоде у 3 детей возникли осложнения. Перипанкреатические жидкостные скопления в 2 наблюдениях были дренированы трансгастральной эндоскопической тонкоигольной пункцией. После энуклеации инсулиномы из крючковидного отростка поджелудочной железы у 1 ребенка развился очаговый панкреонекроз, что потребовало выполнения пилоросохраняющей панкреатодуоденальной резекции. У всех детей достигнут хороший клинический эффект в виде купирования симптомов и отсутствия эпизодов гипогликемии. В сроки от 1,5 до 5 лет рецидива заболевания не отмечено.</p></sec><sec><title>ЗАКЛЮЧЕНИЕ</title><p>ЗАКЛЮЧЕНИЕ. Наш опыт свидетельствует, что при уточненной локализации инсулиномы в поджелудочной железе с помощью эндоУЗИ и интраоперационной сонографии возможно выполнение лапароскопических операций.</p></sec><sec><title> </title><p> </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>BACKROUND</title><p>BACKROUND: Insulinoma is a tumor of β-cells of the islets of Langerhans, secreting an excessive amount of insulin, which is manifested by attacks of hypoglycemic symptoms Diagnosis of insulinomas localization in the pancreas can be extremely difficult and should include all available methods of radiation diagnosis. The only radical way to treat insulinoma is surgical. Traditionally, these operations were performed in the open version. There are only isolated publications on the performance of laparoscopic interventions in children with insulinomas.</p></sec><sec><title>AIM</title><p>AIM: To present our experience of using laparoscopic technologies in the treatment of children with insulinomas of various localizations.</p></sec><sec><title>MATERIALS AND METHODS</title><p>MATERIALS AND METHODS: In the period from 2016 to 2023, 12 girls aged 7 to 17 years were operated on for pancreatic insulinoma. The average age of the patients was 12.5±3.1 years.</p></sec><sec><title>RESUITS</title><p>RESUITS: All operations were completed in the laparoscopic version, there were no conversions. There were no intraoperative complications. In the early postoperative period, 3 children had complications. Parapancreatic fluid accumulations in 2 cases were drained by transgastric endoscopic fine needle puncture. After enucleation of insulinoma from the hookshaped process of the pancreas, 1 child developed focal pancreatic necrosis, which required pylori-preserving pancreatoduodenal resection. In all other cases, the postoperative period proceeded smoothly. All children have achieved a good clinical effect in the form of relief of symptoms and the absence of episodes of hypoglycemia. There was no recurrence of the disease in the period from 1.5 to 5 years.</p></sec><sec><title>CONCLUSIONS</title><p>CONCLUSIONS: Experience shows that with the specified localization of insulinoma in the pancreas, laparoscopic operations can be performed using EUS and intraoperative sonography.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>поджелудочная железа</kwd><kwd>дети</kwd><kwd>инсулинома</kwd><kwd>лапароскопия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreas</kwd><kwd>children</kwd><kwd>insulinoma</kwd><kwd>laparoscopy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Liang M, Jiang J, Dai H, Hong X, Han X, et.al. Robotic enucleation for pediatric insulinoma with MEN1 syndrome: a case report and literature review. 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