endosergЭндокринная хирургияEndocrine Surgery2306-35132310-3965Типография «Печатных дел Мастер»10.14341/serg12997endoserg-12997Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCASE REPORTSКлинический случай агрессивного клинического течения метастатической параганглиомы забрюшинного пространстваA clinical case of metastatic retroperitoneal paragangliomahttps://orcid.org/0000-0001-7911-2424МарковаТ. Н.MarkovaT. N.

Маркова Татьяна Николаевна - д.м.н., профессор.

Москва

Tatyana N. Markova - MD, PhD, Professor.

Moscow

markovatn18@yandex.ruhttps://orcid.org/0000-0001-7098-4584БельцевичД. Г.BeltsevichD. G.

Бельцевич Дмитрий Германович - д.м.н., профессор.

Москва

Dmitriy G. Beltsevich - MD, PhD, Professor.

Moscow

belts67@gmail.comhttps://orcid.org/0000-0003-1575-8407КаплунЕ. А.KaplunE. A.

Каплун Елена Анатольевна.

Москва

Elena A. Kaplun.

Moscow

caplun.l@yandex.ruhttps://orcid.org/0000-0002-6762-9511КоломейцеваА. A.KolomeytsevaA. A.

Коломейцева Алина Андреевна - к.м.н.

Москва

Alina A. Kolomeytseva - MD, PhD.

Moscow

almed2002@mail.ruhttps://orcid.org/0000-0002-3780-4358БатовМ. А.BatovM. A.

Батов Максим Александрович.

Москва

Maxim A. Batov – MD.

Moscow

md.batov@gmail.comhttps://orcid.org/0000-0001-9065-7791БурякинаС. А.BuryakinaS. A.

Бурякина Светлана Алексеевна - к.м.н.

Москва

Svetlana A. Buryakina - MD, PhD.

Moscow

sburyakina@yandex.ruhttps://orcid.org/0000-0003-2122-2297БондаренкоЕ. В.BondarenkoE. V.

Бондаренко Екатерина Владимировна - к.м.н.

Москва

Ekaterina V. Bondarenko - MD, PhD.

Moscow

ekaterinabondarenko@inbox.ruhttps://orcid.org/0000-0003-1172-3557ПоповС. В.PopovS. V.

Попов Сергей Владимирович - к.б.н.

Москва

Sergey V. Popov – PhD.

Moscow

popov.sergey@endocrincentr.ruhttps://orcid.org/0000-0001-5949-5317ЗахароваВ. В.ZakharovaV. V.

Захарова Виктория Витальевна - к.м.н.

Москва

Viktoria V. Zakharova - MD, PhD.

Moscow

neskvikk@mail.ruhttps://orcid.org/0000-0001-9002-1662ИоутсиВ. А.IoutsiV. A.

Иоутси Виталий Алексеевич - к.х.н.

Москва

Vitaliy A. Ioutsi - PhD.

Moscow

vitalik_org@mail.ruhttps://orcid.org/0009-0008-7016-7355БыченковД. В.BychenkovD. V.

Быченков Денис Владимирович - к.х.н.

Москва

Denis V. Bychenkov - PhD.

Moscow

bychenkov.denis@endocrincentr.ruhttps://orcid.org/0000-0002-3064-6553КирилинаИ. В.KirilinaI. V.

Кирилина Ирина Валерьевна.

Москва

Irina V. Kirilina.

Moscow

kirilina-irina@bk.ruhttps://orcid.org/0000-0002-5634-7877МельниченкоГ. А.MelnichenkoG. A.

Мельниченко Галина Афанасьевна - д.м.н., профессор, академик РАН.

Москва

Galina A. Melnichenko - MD, PhD, acad.

Moscow

teofrast2000@mail.ruhttps://orcid.org/0000-0003-1857-5083РосляковаA. А.RoslyakovaA. A.

Рослякова Анна Александровна - автор национальных клинических рекомендаций по АКР и феохромоцитоме.

117036, Москва, ул. Дм. Ульянова, д. 11

Scopus Author ID 57210394039

Anna A. Roslyakova.

11 Dm. Ulyanova street, 117036 Moscow

Scopus Author ID 57210394039

aroslyakova@yandex.ruФГБОУ ВО Московский государственный медико-стоматологический университет им. А.И. Евдокимова; ГБУЗ «ГКБ №52 ДЗМ»РоссияMoscow State University of Medicine and Dentistry; Moscow City Clinical Hospital 52Russian FederationФГБУ «НМИЦ эндокринологии» Минздрава РоссииРоссияNational Medical Research Center for EndocrinologyRussian FederationГБУЗ «ГКБ №52 ДЗМ»РоссияMoscow City Clinical Hospital 52Russian FederationФГБУ «НМИЦ эндокринологии» Минздрава России; МНИОИ им. П.А. Герцена — филиал ФГБУ «НМИЦ радиологии» Минздрава РоссииРоссияNational Medical Research Center for Endocrinology; P. Hertsen Moscow Oncology Research Institute – a branch of National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationRussian FederationМНИОИ им. П.А. Герцена — филиал ФГБУ «НМИЦ радиологии» Минздрава РоссииРоссияP. Hertsen Moscow Oncology Research Institute – a branch of National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationRussian Federation2025040620251913242Copyright © Маркова Т.Н., Бельцевич Д.Г., Каплун Е.А., Коломейцева А.A., Батов М.А., Бурякина С.А., Бондаренко Е.В., Попов С.В., Захарова В.В., Иоутси В.А., Быченков Д.В., Кирилина И.В., Мельниченко Г.А., Рослякова A.А., 20252025Маркова Т.Н., Бельцевич Д.Г., Каплун Е.А., Коломейцева А.A., Батов М.А., Бурякина С.А., Бондаренко Е.В., Попов С.В., Захарова В.В., Иоутси В.А., Быченков Д.В., Кирилина И.В., Мельниченко Г.А., Рослякова A.А.Markova T.N., Beltsevich D.G., Kaplun E.A., Kolomeytseva A.A., Batov M.A., Buryakina S.A., Bondarenko E.V., Popov S.V., Zakharova V.V., Ioutsi V.A., Bychenkov D.V., Kirilina I.V., Melnichenko G.A., Roslyakova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surg-endojournals.ru/jour/article/view/12997

Феохромоцитома (ФХЦ) и параганглиома (ПГ) являются злокачественными нейроэндокринными опухолями (НЭО) параганглионарного происхождения, продуцирующими биологически активные вещества и характеризующимися вариабельным клиническим течением. В настоящее время основным методом лечения НЭО является радикальное хирургическое лечение, тем не менее, сохраняется пожизненный риск рецидива опухоли или манифестации ее отдаленных метастазов. В статье представлен клинический случай рецидивирующей ПГ забрюшинного пространства, случайно выявленной во время госпитализации в эндокринологическом отделении по поводу декомпенсации сахарного диабета (СД). В представленном клиническом случае ПГ послужила причиной развития острого нарушения мозгового кровообращения, артериальной гипертензии, СД, нарушений ритма сердца, потенциально предотвратимых при своевременной диагностике заболевания. Особенностью выявленной ПГ явилось ее рецидивирующее течение, несмотря на неоднократные оперативные вмешательства.

Pheochromocytoma (PCС) and paraganglioma (PG) are malignant neuroendocrine tumors (NEO) of paraganglionic origin, producing biologically active substances and characterized by a variable clinical course. Currently, the main method of treatment of PCС and PG is radical surgical treatment; nevertheless, there is a life-long risk of tumor recurrence as well as distant metastases. Here we present a clinical case of recurrent retroperitoneal PG incidentally detected during hospitalization for decompensated diabetes mellitus (DM). In the case PG caused acute cerebral circulatory failure, arterial hypertension, DM, heart rhythm disorders, potentially preventable with timely diagnosis of the disease. The peculiarity of the detected PG was its recurrent course despite repeated surgical interventions.

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