endosergЭндокринная хирургияEndocrine Surgery2306-35132310-3965Типография «Печатных дел Мастер»10.14341/2306-3513-2011-1-39-44endoserg-4025Research ArticleСтатьиArticlesИнтраоперационное кровоизлияние в аденому гипофиза как причина ремиссии акромегалииIntraoperation haemorrhage into hypophysis adenoma as the cause of acromegaly remissionAzizyanV Nvazizyan@mail.ruGrigorjevA U-IvaschenkoO V-MolitvoslovovaN N-20111503201151№1 (2011)3944Copyright © Azizyan V.N., Grigorjev A.U., Ivaschenko O.V., Molitvoslovova N.N., 20112011Azizyan V.N., Grigorjev A.U., Ivaschenko O.V., Molitvoslovova N.N.Azizyan V.N., Grigorjev A.U., Ivaschenko O.V., Molitvoslovova N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surg-endojournals.ru/jour/article/view/4025

Приводится описание развития спонтанной ремиссии акромегалии после интраоперационного кровотечения с последующим кровоизлиянием в строму опухоли. Описанные в литературе наблюдения спонтанной ремиссии акромегалии были связаны в основном с кровоизлиянием или ишемической апоплексией аденомы гипофиза без хирургического вмешательства. Чаще всего оба процесса, особенно кровоизлияние, сопровождались развитием пангипопитуитаризма. Случаи, при которых имела место нормализация уровня только гормона роста, единичны.

In this article we describe a spontaneous remission of acromegaly of intraoperative bleeding, with subsequent hemorrhage into the tumor. The cases of spontaneous remission of acromegaly described in the literature have been associated mainly with hemorrhage or ischemic apoplexy pituitary adenoma without surgical intervention. Most often, both processes, especially hemorrhage are accompanied by the development of panhypopituitarism. Cases in which there was a normalization of only growth hormone isolated.

акромегалияаденома гипофизакровоизлияниеремиссия акромегалииacromegalypituitary adenomapituitary hemorrhageremission acromegalyReferencesZervas N.T. Surgical results for pituitary adenomas: results of an international survey. In: Black P.McL., Zervas N.T., Ridgway E.C. Jr., Martin J.B. (eds.) Secretory Tumors of the Pituitary Gland. New York: Raven Press; 1984. 377–385.Zervas N.T. Surgical results for pituitary adenomas: results of an international survey. In: Black P.McL., Zervas N.T., Ridgway E.C. Jr., Martin J.B. (eds.) Secretory Tumors of the Pituitary Gland. New York: Raven Press; 1984. 377–385.Ciric I., Ragin A., Baumgartner C., Pierce D. Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience. Neurosurgery 1997; 40: 225–236.Ciric I., Ragin A., Baumgartner C., Pierce D. Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience. Neurosurgery 1997; 40: 225–236.Imaki T., Yamada S., Harada S. et al. Amelioration of acromegaly after pituitary infarction due to gastrointestinal hemorrhage from gastric ulcer. Endocr. J. 1999; 46 (1): 147–151.Imaki T., Yamada S., Harada S. et al. Amelioration of acromegaly after pituitary infarction due to gastrointestinal hemorrhage from gastric ulcer. Endocr. J. 1999; 46 (1): 147–151.Louwerens M., de Herder W.W., Postema P.T. et al. Pituitary insufficiency and regression of acromegaly caused by pituitary apoplexy following cerebral angiography. Eur. J. Endocr. 1996;134 (6): 737–740.Louwerens M., de Herder W.W., Postema P.T. et al. Pituitary insufficiency and regression of acromegaly caused by pituitary apoplexy following cerebral angiography. Eur. J. Endocr. 1996;134 (6): 737–740.Wichers M., Kristof R.A., Springer W. et al. Pituitary apoplexy with spontaneous cure of acromegaly and its possible relation to Gd-DTPA-administration. Acta Neurochir. (Wien) 1997;139 (10): 992–994.Wichers M., Kristof R.A., Springer W. et al. Pituitary apoplexy with spontaneous cure of acromegaly and its possible relation to Gd-DTPA-administration. Acta Neurochir. (Wien) 1997;139 (10): 992–994.Nishioka H., Haraoka J., Miki T. Spontaneous remission of functioning pituitary adenomas without hypopituitarism following infarctive apoplexy: two case reports. Endocr. J. 2005;52 (1): 117–123.Nishioka H., Haraoka J., Miki T. Spontaneous remission of functioning pituitary adenomas without hypopituitarism following infarctive apoplexy: two case reports. Endocr. J. 2005;52 (1): 117–123.Laws E.R. Jr., Sheehan J.P. (eds). Pituitary Surgery – A Modern Approach. Front Horm Res. Basel: Karger, 2006; 34: 256–278.Laws E.R. Jr., Sheehan J.P. (eds). Pituitary Surgery – A Modern Approach. Front Horm Res. Basel: Karger, 2006; 34: 256–278.

The authors declare that there are no conflicts of interest present.