endosergЭндокринная хирургияEndocrine Surgery2306-35132310-3965Типография «Печатных дел Мастер»10.14341/serg201344-13endoserg-6572Research ArticleСтатьиArticlesПрогностические критерии клинического течения и диагностика медуллярного рака щитовидной железыDiagnosis of medullary thyroid cancer and prognostic factors of disease aggressivenessGazizovaD O

aspirant FGBU ENTs

-BeltsevichD G

doktor med. nauk, gl. nauch. sotr. otd. khirurgii FGBU ENTs

beltsevich@rambler.ruTiulpakovA N

doktor med. nauk, zav. otdeleniem nasledstvennykh endokrinopatiy FGBU ENTs

-SoldatovaT V

kand. med. nauk, zav. otdeleniem ul'trazvukovoy diagnostiki FGBU ENTs

-IlyinA V

zav. otdeleniem klinicheskoy biokhimii FGBU ENTs

-20131512201374№4 (2013)413Copyright © Gazizova D.O., Beltsevich D.G., Tiulpakov A.N., Soldatova T.V., Ilyin A.V., 20132013Gazizova D.O., Beltsevich D.G., Tiulpakov A.N., Soldatova T.V., Ilyin A.V.Gazizova D.O., Beltsevich D.G., Tiulpakov A.N., Soldatova T.V., Ilyin A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surg-endojournals.ru/jour/article/view/6572

Проведено ретроспективно-проспективное клиническое аналитическое исследование 137 пациентов с медулляр- ным раком щитовидной железы (МРЩЖ). Выявлена крайне низкая 35%-ная чувствительность тонкоигольной аспи- рационной биопсии и высокая чувствительность исследования уровня базального кальцитонина в диагностике МРЩЖ. Представлены результаты изучения спектра герминальных и спорадических мутаций генов RET и RAS на российской популяции, доказано влияние вида мутации на агрессивность течения МРЩЖ.

In the study were enrolled 137 patients with medullary thyroid cancer (MTC). Low 35%-sensitivity of FNAC and high accuracy of basal calcitonin in MTC diagnostics were found. Mutation analysis of the RET pro- tooncogene in familial and sporadic MTC, RAS -gene in sporadic MTC were done. The correlation between type of the mutation and disease aggressiveness was found.

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The authors declare that there are no conflicts of interest present.