endosergЭндокринная хирургияEndocrine Surgery2306-35132310-3965Типография «Печатных дел Мастер»10.14341/serg201429-13endoserg-6758Research ArticleСтатьиArticlesТрудности в диагностике АКТГ-эктопических опухолей. Клинический случайDifficulties in the Diagnosis of ACTH-ectopic Tumors. Case ReportKuznetsovN S

Endocrinology Research Centre

-MarovaE I

Endocrinology Research Centre

-LatkinaN V

Endocrinology Research Centre

-LanshchakovK V

Endocrinology Research Centre

-DobrevaE A

Endocrinology Research Centre

-KrylovV V

Endocrinology Research Centre

-20141506201482№2 (2014)913Copyright © Kuznetsov N.S., Marova E.I., Latkina N.V., Lanshchakov K.V., Dobreva E.A., Krylov V.V., 20142014Kuznetsov N.S., Marova E.I., Latkina N.V., Lanshchakov K.V., Dobreva E.A., Krylov V.V.Kuznetsov N.S., Marova E.I., Latkina N.V., Lanshchakov K.V., Dobreva E.A., Krylov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.surg-endojournals.ru/jour/article/view/6758

В настоящее время топическая диагностика АКТГ-продуцирующих нейроэндокринных опухолей различной лока- лизации является камнем преткновения для эндокринологов всего мира. Несмотря на значительное совершенствование существующих методов исследования, у 9-19% пациентов локализация источника эктопической секреции АКТГ остается невыявленной на протяжении всей жизни. При этом даже регулярное проведение повторных лабораторных тестов и применение визуализирующих методов исследования не позволяют определить локализацию первичной опухоли. В настоящей статье описан клинический случай, особенностью которого является длительный период диагностирования синдрома эктопической продукции АКТГ. Однако данный пример демонст- рирует нам, насколько важен упорный поиск первичного очага нейроэндокринной опухоли, что позволяет существенно снизить морбидность и смертность пациентов данного профиля и улучшить прогноз.

At the present time topical diagnosis of ACTH-producing neuroendocrine tumors of different localization is the most challenging problem for endocrinologists around the world. Despite the significant improvement of existing diagnostic techniques, in 9-19% localization of the source of ectopic secretion ACTH re-mains undetected throughout life. Thus even regular using of routine laboratory tests and visual methods of diag- nosis do not allow to reveal the primary tumor. This article describes a case report, that is particular by a long period of ectopic ACTH syndrome detection. However, this demonstrates the importance of inten-sive and prolonged diagnosis of primary tumor, that can significantly reduce the morbidity and mortality of these patients and improve their prognosis.

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The authors declare that there are no conflicts of interest present.