Draft of clinical guidelines for the diagnosis and treatment of medullary thyroid cancer in adult patients
N. V. Severskaya,
E. L. Choinzonov,
I. V. Reshetov,
S. A. Ivanov,
A. P. Polyakov,
M. A. Kropotov,
A. M. Mudunov,
V. V. Polkin,
P. A. Isaev,
A. A. Ilyin,
D. G. Beltsevich,
V. E. Vanushko,
P. O. Rumyantsev,
G. A. Melnichenko,
Yu. V. Alymov,
I. S. Romanov,
A. V. Ignatova,
E. V. Borodavina,
V. V. Krylov,
A. Yu. Shurinov,
Z. A. Radjabova,
D. E. Kulbakin,
A. A. Nevolskikh,
A. R. Gevorkov,
E. V. Khmelevsky,
S. I. Kutukova,
A. O. Guz,
I. V. Sleptsov,
R. A. Chernikov,
A. M. Stepanova,
N. A. Falaleeva,
S. O. Podvyaznikov,
N. A. Rubtsova,
A. N. Rudyk,
Sh. I. Musin,
I. A. Gulidov,
L. Yu. Vladimirova,
T. Yu. Semiglazova,
T. A. Aghababyan,
E. V. Kostromina https://doi.org/10.14341/serg12794
Abstract
The article presents a draft of clinical recommendations for the diagnosis and treatment of medullary thyroid cancer in adult patients, which provides a modern examination algorithm, discusses the basic principles of laboratory, instrumental diagnostics and treatment approaches.
About the Authors
N. V. Severskaya
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Natalia V. Severskaya, MD, PhD
Obninsk
E. L. Choinzonov
Tomsk National Research Medical Center; Siberian State Medical University
Evgeniy L. Choinzonov, MD, PhD, acad.
Tomsk
I. V. Reshetov
The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Igor V. Reshetov, MD, PhD, acad.
Moscow
S. A. Ivanov
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Sergei А. Ivanov, MD, PhD, Professor of the Russian Academy
of Sciences
Obninsk
A. P. Polyakov
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Andrey P. Polyakov, MD, PhD, docent
Moscow
M. A. Kropotov
Federal State Budgetary Scientific Institution “N.N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation
Mikhail A. Kropotov, MD, PhD
Moscow
A. M. Mudunov
Lapino Cancer Center
Ali M. Mudunov, MD, PhD, Professor of the Russian Academy
of Sciences
Lapino village
V. V. Polkin
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Vyacheslav V. Polkin, MD, PhD
Obninsk
P. A. Isaev
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Pavel A. Isaev, MD, PhD
Obninsk
A. A. Ilyin
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Alexey A. Ilyin, MD, PhD
Obninsk
D. G. Beltsevich
Endocrinology Research Centre
Dmitry G. Beltsevich, MD, PhD, Prof.
11 Dm. Ulyanova street, 117292 Moscow
V. E. Vanushko
Endocrinology Research Centre
Vladimir E. Vanushko, MD, PhD, Prof
11 Dm. Ulyanova street, 117292 Moscow
P. O. Rumyantsev
International Medical Center “SOGAZ”
Pavel O. Rumyantsev, MD, PhD
Saint-Petersburg
G. A. Melnichenko
Endocrinology Research Centre
Galina A. Melnichenko, MD, PhD, Prof, acad.
Moscow
Yu. V. Alymov
Federal State Budgetary Scientific Institution “N.N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation
Yuri V. Alymov, MD, PhD
Moscow
I. S. Romanov
Federal State Budgetary Scientific Institution “N.N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation
Ilya S. Romanov, MD, PhD
Moscow
A. V. Ignatova
Federal State Budgetary Scientific Institution “N.N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
Anastasia V. Ignatova, MD, PhD
Moscow
E. V. Borodavina
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Ekaterina V. Borodavina
Obninsk
V. V. Krylov
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Valery V. Krylov, MD, PhD
Obninsk
A. Yu. Shurinov
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Andrey Yu. Shurinov
Obninsk
Z. A. Radjabova
Federal State Budget Institution «N.N. Petrov National Medical Research Centre of Oncology» Ministry of public health of Russian Federation
Zamira A. Radjabova, MD, PhD
Saint-Petersburg
D. E. Kulbakin
Tomsk National Research Medical Center
Denis E. Kulbakin, MD, PhD
Tomsk
A. A. Nevolskikh
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Alexey A. Nevolskikh, MD, PhD
Obninsk
A. R. Gevorkov
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Artem R. Gevorkov, MD, PhD
Moscow
E. V. Khmelevsky
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Evgeny V. Khmelevsky, MD, PhD, Prof.
Moscow
S. I. Kutukova
Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation; St. Petersburg State Institution City Clinical Oncological Dispensary
Svetlana I. Kutukova, MD, PhD, docent
Saint-Petersburg
A. O. Guz
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Alexander O. Guz, MD, PhD
Chelyabinsk
I. V. Sleptsov
N.I. Pirogov Clinic of High Medical Technologies of St. Petersburg State University; North-Western Center of Endocrinology and Endocrine Surgery
Ilya V. Sleptsov, MD, PhD, Prof.
Saint-Petersburg
R. A. Chernikov
N.I. Pirogov Clinic of High Medical Technologies of St. Petersburg State University
Roman A. Chernikov, MD, PhD
Saint-Petersburg
A. M. Stepanova
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Alexandra M. Stepanova
Moscow
N. A. Falaleeva
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Natalia A. Falaleeva, MD, PhD
Obninsk
S. O. Podvyaznikov
Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy
of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation
Sergey O. Podvyaznikov, MD, PhD, Prof.
Moscow
N. A. Rubtsova
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Natalia A. Rubtsova, MD, PhD
Moscow
A. N. Rudyk
Kazan State Medical Academy; Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Tatarstan named after Professor M.Z.Segal
Andrey N. Rudyk, MD, PhD
Kazan
Sh. I. Musin
State Autonomous Healthcare Institution Republican Clinical Oncological Dispensary of the Ministry of Health
of the Republic of Bashkortostan
Shamil I. Musin, MD, PhD
Ufa
I. A. Gulidov
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Igor A. Gulidov, MD, PhD, Prof.
Obninsk
L. Yu. Vladimirova
Federal State Budgetary Scientific Institution “ National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation
Liubov Yu. Vladimirova, MD, PhD, Prof.
Rostov-on-Don
T. Yu. Semiglazova
Federal State Budget Institution «N.N. Petrov National Medical Research Centre of Oncology» Ministry of public health of Russian Federation
Tatiana Yu. Semiglazova, MD, PhD, docent
Saint-Petersburg
T. A. Aghababyan
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Tatevik А. Aghababyan, MD, PhD
Obninsk
E. V. Kostromina
Federal State Budget Institution «N.N. Petrov National Medical Research Centre of Oncology» Ministry of public health of Russian Federation; Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation
Ekaterina V. Kostromina, MD, PhD
Saint-Petersburg
References
1. Бржезовский В.Ж. Опухоли щитовидной железы. В кн.: А.И. Пачес и др. Опухоли головы и шеи. 5-е изд., доп. и перераб. М.: Практическая медицина, 2013. С. 339–359.
2. Диагностика и лечение медуллярного рака щитовидной железы. национальные клинические рекомендации. Опухоли головы и шеи. 2013;(4):36-45.
3. Газизова Д.О., Бельцевич Д.Г. Современный взгляд на проблему диагностики и лечения медуллярного рака щитовидной железы. Эндокринная хирургия 2013;(3):4–21.
4. Wells SA Jr, Asa SL, Dralle H, et al. American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid. 2015 Jun;25(6):567-610. doi: 10.1089/thy.2014.0335.
5. Howlader N., Noone A.M., Krapcho M. et al. (eds). SEER Cancer Statistics Review, 1975–2014, National Cancer Institute. Available at: https://seer.cancer.gov/csr/1975_2014
6. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). Thyroid Carcinoma. Version 3.2022 https://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf
7. Allelein S, Ehlers M, Morneau C, et al. Measurement of Basal Serum Calcitonin for the Diagnosis of Medullary Thyroid Cancer. Horm Metab Res. 2018 Jan;50(1):23-28. doi: 10.1055/s-0043-122237.
8. Costante G, Meringolo D, Durante C, et al. Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. J Clin Endocrinol Metab. 2007 Feb;92(2):450-5. doi: 10.1210/jc.2006-1590.
9. Giannetta E, Guarnotta V, Altieri B, et al. ENDOCRINE TUMOURS: Calcitonin in thyroid and extra-thyroid neuroendocrine neoplasms: the two-faced Janus. Eur J Endocrinol. 2020 Dec;183(6):R197-R215. doi: 10.1530/EJE-20-0506.
10. Северская Н.В., Ильин А.А., Чеботарева И.В. и др. Исследование кальцитонина у пациентов с узловыми образованиями щитовидной железы для скрининга медуллярного рака: «серая зона». Опухоли головы и шеи 2022;12(2):79–88. DOI: 10.17650/2222-1468-2022-12-2-79-88.
11. Trimboli P, Giannelli J, Marques B, et al. Head-to-head comparison of FNA cytology vs. calcitonin measurement in FNA washout fluids (FNA-CT) to diagnose medullary thyroid carcinoma. A systematic review and meta-analysis. Endocrine. 2022 Jan;75(1):33-39. doi: 10.1007/s12020-021-02892-x.
12. Ильин А. А., Севрюков Ф. Е., Исаев П. А. и др. Дооперационная диагностика медуллярного рака щитовидной железы, сонографические находки // Злокачественные опухоли. — 2020. — Т. 10. — № 3S1. — С. 104-105. — EDN RYHGYA.
13. Alexander EK, Cooper D. The importance, and important limitations, of ultrasound imaging for evaluating thyroid nodules. JAMA Intern Med. 2013 Oct 28;173(19):1796-7. doi: 10.1001/jamainternmed.2013.8278.
14. Friedrich-Rust M, Meyer G, Dauth N, et al. Interobserver agreement of Thyroid Imaging Reporting and Data System (TIRADS) and strain elastography for the assessment of thyroid nodules. PLoS One. 2013 Oct 24;8(10):e77927. doi: 10.1371/journal.pone.0077927.
15. Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009 Jan;45(2):228-47. doi: 10.1016/j.ejca.2008.10.026.
16. Trimboli P, Castellana M, Virili C, et al. Efficacy of Vandetanib in Treating Locally Advanced or Metastatic Medullary Thyroid Carcinoma According to RECIST Criteria: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2018 May 3;9:224. doi: 10.3389/fendo.2018.00224.
17. Ramos HE, Hecht F, Berdelou A, et al. Long-term follow-up and safety of vandetanib for advanced medullary thyroid cancer. Endocrine. 2021 Feb;71(2):434-442. doi: 10.1007/s12020-020-02426-x.
18. Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013 Oct 10;31(29):3639-46. doi: 10.1200/JCO.2012.48.4659.
19. Spitzweg C, Morris JC, Bible KC. New drugs for medullary thyroid cancer: new promises? Endocr Relat Cancer. 2016 Jun;23(6):R287-97. doi: 10.1530/ERC-16-0104.
20. Capdevila J, Klochikhin A, Leboulleux S, et al. A Randomized, Double-Blind Noninferiority Study to Evaluate the Efficacy of the Cabozantinib Tablet at 60mg Per Day Compared with the Cabozantinib Capsule at 140mg Per Day in Patients with Progressive, Metastatic Medullary Thyroid Cancer. Thyroid. 2022 May;32(5):515-524. doi: 10.1089/thy.2022.0027
21. Wirth LJ, Sherman E, Robinson B, et al. Efficacy of Selpercatinib in RET-Altered Thyroid Cancers. N Engl J Med. 2020 Aug 27;383(9):825-835. doi: 10.1056/NEJMoa2005651.
22. Subbiah V, Hu MI, Wirth LJ, et al. Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study. Lancet Diabetes Endocrinol. 2021 Aug;9(8):491-501. doi: 10.1016/S2213-8587(21)00120-0.
23. Ravaud A, de la Fouchardière C, Caron P, et al. A multicenter phase II study of sunitinib in patients with locally advanced or metastatic differentiated, anaplastic or medullary thyroid carcinomas: mature data from the THYSU study. Eur J Cancer. 2017 May;76:110-117. doi: 10.1016/j.ejca.2017.01.029.
24. Bible KC, Suman VJ, Molina JR, et al. Endocrine Malignancies Disease Oriented Group, Mayo Clinic Cancer Center, and the Mayo Phase 2 Consortium. A multicenter phase 2 trial of pazopanib in metastatic and progressive medullary thyroid carcinoma: MC057H. J Clin Endocrinol Metab. 2014 May;99(5):1687-93. doi: 10.1210/jc.2013-3713.
25. Schlumberger M, Jarzab B, Cabanillas ME, et al. A Phase II Trial of the Multitargeted Tyrosine Kinase Inhibitor Lenvatinib (E7080) in Advanced Medullary Thyroid Cancer. Clin Cancer Res. 2016 Jan 1;22(1):44-53. doi: 10.1158/1078-0432.CCR-15-1127.
26. Vuong HG, Ho ATN, Tran TTK, et al. Efficacy and toxicity of sorafenib in the treatment of advanced medullary thyroid carcinoma: A systematic review and meta-analysis. Head Neck. 2019 Aug;41(8):2823-2829. doi: 10.1002/hed.25832.
27. Marabelle A, Fakih M, Lopez J, et al. Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study. Lancet Oncol. 2020 Oct;21(10):1353-1365. doi: 10.1016/S1470-2045(20)30445-9.
28. Terezakis SA, Lee NY. The role of radiation therapy in the treatment of medullary thyroid cancer. J Natl Compr Canc Netw. 2010 May;8(5):532-40; quiz 541. doi: 10.6004/jnccn.2010.0041.
29. Fromigué J, De Baere T, Baudin E, et al. Chemoembolization for liver metastases from medullary thyroid carcinoma. J Clin Endocrinol Metab. 2006 Jul;91(7):2496-9. doi: 10.1210/jc.2005-2401.
30. Исаев П.А., Полькин В.В., Петров Л.О. и др. Хирургическое лечение метастазов медуллярного рака щитовидной железы в печень. Вопросы онкологии 2022; 68(4): https://doi.org/10.37469/0507-3758-2022-68-4-450-456
31. Kim IY, Kondziolka D, Niranjan A, et al. Gamma knife radiosurgery for metastatic brain tumors from thyroid cancer. J Neurooncol. 2009 Jul;93(3):355-9. doi: 10.1007/s11060-008-9783-2.
32. Börcek P, Asa SL, Gentili F, et al. Brain metastasis from medullary thyroid carcinoma. BMJ Case Rep. 2010 Dec 29; 2010. doi: 10.1136/bcr.09.2010.3301.
33. Breelyn A Wilky, David M Loeb. Beyond Palliation: Therapeutic Applications of 153Samarium-EDTMP. Clin Exp Pharmacol. 2013 Jun;3(3):1000131. doi: 10.4172/2161-1459.1000131
34. Reyhaneh Manafi-Farid, Fardad Masoumi, Ghasemali Divband, Bahare Saidi, Bahar Ataeinia, Fabian Hertel, Gregor SchweighoferZwink , Agnieszka Morgenroth , Mohsen Beheshti. Targeted Palliative Radionuclide Therapy for Metastatic Bone Pain. J Clin Med. 2020 Aug 12;9(8):2622. doi: 10.3390/jcm9082622
35. Nicole M. Iñiguez-Ariza,a,b Keith C. Bible,c, and Bart L. Clarkea. Bone metastases in thyroid cancer. J Bone Oncol. 2020 Apr; 21: 100282. Published online 2020 Feb 19. doi: 10.1016/j.jbo.2020.100282
36. Fernanda Andrade, Danielle Probstner, Marcus Decnop, Daniel Bulzico, Denise Momesso, Rossana Corbo , Mario Vaisman , Fernanda Vaisman. The Impact of Zoledronic Acid and Radioactive Iodine Therapy on Morbi-Mortality of Patients with Bone Metastases of Thyroid Cancer Derived from Follicular Cells. Eur Thyroid J. 2019 Jan;8(1):46-55. doi: 10.1159/000493190. Epub 2018 Oct 3.
37. Juan Lv , Fu-Kun Chen , Chao Liu , Peng-Jie Liu , Zhi-Ping Feng, Li Jia, Zhi-Xian Yang , Fei Hou , Zhi-Yong Deng. Zoledronic acid inhibits thyroid cancer stemness and metastasis by repressing M2-like tumor-associated macrophages induced Wnt/β-catenin pathway. Life Sci. 2020 Sep 1;256:117925. doi: 10.1016/j.lfs.2020.117925. Epub 2020 Jun 6.
38. Поляков В. Г., Шишков Р.В., Ильин А.А. и др. Результаты профилактической тиреоидэктомии у носителей герминальной мутации в гене RET в семьях с наследственными формами медуллярного рака щитовидной железы. Kлиническая и экспериментальная тиреоидология 2016; 12(1):22-33. doi: 10.14341/ket2016122-33/
39. Hughes P, Healy NA, Grant C, Ryan JM. Treatment of hepatic metastases from medullary thyroid cancer with transarterial embolisation. Eur Radiol Exp. 2017;1(1):9. doi:10.1186/s41747-017-0013-6
Supplementary files
|
|
1. Рисунок. Алгоритм действий врача | |
| Subject | ||
| Type | Исследовательские инструменты | |
View
(201KB)
|
Indexing metadata ▾ | |
Review
For citations:
Severskaya N.V., Choinzonov E.L., Reshetov I.V., Ivanov S.A., Polyakov A.P., Kropotov M.A., Mudunov A.M., Polkin V.V., Isaev P.A., Ilyin A.A., Beltsevich D.G., Vanushko V.E., Rumyantsev P.O., Melnichenko G.A., Alymov Yu.V., Romanov I.S., Ignatova A.V., Borodavina E.V., Krylov V.V., Shurinov A.Yu., Radjabova Z.A., Kulbakin D.E., Nevolskikh A.A., Gevorkov A.R., Khmelevsky E.V., Kutukova S.I., Guz A.O., Sleptsov I.V., Chernikov R.A., Stepanova A.M., Falaleeva N.A., Podvyaznikov S.O., Rubtsova N.A., Rudyk A.N., Musin Sh.I., Gulidov I.A., Vladimirova L.Yu., Semiglazova T.Yu., Aghababyan T.A., Kostromina E.V. Draft of clinical guidelines for the diagnosis and treatment of medullary thyroid cancer in adult patients. Endocrine Surgery. 2022;16(3):5-23. (In Russ.) https://doi.org/10.14341/serg12794
Views:
1780
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
