The pathogenesis of Charcot osteoarthropathy: the role of the peripheral nervous system
https://doi.org/10.14341/serg201445-14
Abstract
Neuroosteoarthropathy is a rare, but devastating complication affecting patients with peripheral neuropathy. It is a progressive, destructive condition that is characterised by progressive bone and joint deterioration of the foot leading to permanent incapacity. Nowadays, diabetes mellitus is by far the most common etiology of CNO (Charcot neuro-osteoarthropathy), especially if it affects the foot or ankle.
The cause of the condition is still controversial among experts. In particular, new data have emerged on the central role of RANK/RANKL/OPG in the pathogenesis of this complication, also known as Charcot foot. No pharmacological methods of therapy have proven effective to date. Very little progress has been made in treating this condition since the days of Jean-Martin Charcot. Today, the universally accepted treatment involves completely relieving pressure from the limb using a polymer retaining bandage. The aim of this review is to analyze research into the pathogenesis of CNO and our potential to better understand the nature of this condition.
Particular attention is paid to modern concept of neuroosteopathology, according to which neuropathy is crucial to developing acute osseous pathology. Revealing new aspects of CNO pathogenesis can help extend therapeutic resources for treating this patient group.
About the Authors
Galstyan Gagik Radikovich
Endocrinology Research Centre, Moscow
Russian Federation
MD, PhD, Professor
Competing Interests: Авторы декларируют отсутствие двойственности (конфликта) интересов и финансовой поддержки при написании данной статьи.
Russian Federation
MD, PhD, Professor
Competing Interests: Авторы декларируют отсутствие двойственности (конфликта) интересов и финансовой поддержки при написании данной статьи.
Yuliya Andreevna Kaminarskaya
Endocrinology Research Centre, Moscow
Russian Federation
MD
Competing Interests:
Russian Federation
MD
Competing Interests:
Авторы декларируют отсутствие двойственности (конфликта) интересов и финансовой поддержки при написании данной статьи.
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Radikovich G.G., Kaminarskaya Yu.A. The pathogenesis of Charcot osteoarthropathy: the role of the peripheral nervous system. Endocrine Surgery. 2014;8(4):5-14. (In Russ.) https://doi.org/10.14341/serg201445-14
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ISSN 2310-3965 (Online)
