Primary hyperparathyroidism caused by an ectopic parathyroid adenoma in the mediastinum (case report)
Y. B. Topolnitskiy,
T. A. Milovanova,
D. G. Apalkov,
Е. Е. Bibik,
A. I. Goncharova,
M. O. Tsvetukhin https://doi.org/10.14341/serg12840
Abstract
Recently, primary hyperparathyroidism, which represents a medical and socially significant problem, has become increasingly relevant. The high prevalence of forms without pronounced clinical symptoms, as well as the low awareness of doctors regarding this pathology, lead to late diagnosis, delayed initiation of treatment and, as a consequence, the development of serious multisystem complications with a higher risk of premature death. At the same time, early diagnosis is based on relatively laboratory tests — serum calcium and parathyroid hormone, and visualization of the adenoma in most cases is provided by ultrasound examination and scintigraphy. This article is a case report of primary hyperparathyroidism caused by an ectopic parathyroid adenoma located in the mediastinum, when late treatment led to the patient’s long-term suffering and the development of severe complications.
About the Authors
Y. B. Topolnitskiy
Tomsk Regional Clinical Hospital; Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
Evgeniy B. Topolnitskiy -MD, ScD, docent.
Tomsk
Competing Interests:
none
T. A. Milovanova
Tomsk Regional Clinical Hospital
Russian Federation
Competing Interests:
Russian Federation
Тatyana A. Milovanova -MD, PhD.
Tomsk
Competing Interests:
none
D. G. Apalkov
Tomsk Regional Clinical Hospital; Siberian State Medical University
Russian Federation
Competing Interests:
Russian Federation
Dobrynya G. Apalkov - MD.
96 Ivana-Chernykh str., 634063, Tomsk
Competing Interests:
none
Е. Е. Bibik
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Ekaterina E. Bibik - MD, PhD.
Tomsk
Competing Interests:
none
A. I. Goncharova
Tomsk Regional Clinical Hospital
Russian Federation
Competing Interests:
Russian Federation
Alina I. Goncharova - MD, endocrinologist.
Tomsk
Competing Interests:
none
M. O. Tsvetukhin
Tomsk Regional Clinical Hospital
Russian Federation
Competing Interests:
Russian Federation
Mikhail O. Tsvetukhin - MD, terapist.
Tomsk
Competing Interests:
none
References
1. Yanevskaya LG, Karonova TL, Sleptsov IV, et al. Primary hyperparathyroidism: clinical forms and their features. Retrospective study. Clinical and experimental thyroidology. 2019;15(1):19-29. (In Russ.). doi: https://doi.org/https://doi.org/10.14341/ket10213
2. Mokrysheva NG, Eremkina AK, Mirnaya SS, et al. The clinical practice guidelines for primary hyperparathyroidism, short version. Problems of Endocrinology. 2021;67(4):94-124. (In Russ.). doi: https://doi.org/10.14341/probl12801
3. Mokrysheva NG, Dobreva EA, Maganeva IS, et al. Primary hyperparathyroidism in Russia according to the registry. Problems of Endocrinology. 2019;65(4): 300-310. (In Russ.). doi: https://doi.org/10.14341/probl9946
4. Walker MD, Silverberg SJ. Primary hyperparathyroidism. Nat Rev Endocrinol. 2018;14(2):115-125. doi: https://doi.org/10.1038/nrendo.2017.104
5. Zavatta G, Clarke BL. Normocalcemic Primary Hyperparathyroidism: Need for a Standardized Clinical Approach. Endocrinol Metab (Seoul). 2021;36(3):525-535. doi: https://doi.org/10.3803/EnM.2021.1061
6. Vasiliev PV, Skorobogatov MM, Dzhafarova BZ, Semkov NG, Klimovich NV. Surgical treatment of primary hyperparathyroidism with ectopic parathyroid adenoma in the mediastinum. Pacific Medical Journal. 2023;2:73–76. (In Russ.). doi: https://doi.org/10.34215/1609-1175-2023-2-73-76
7. Mokrisheva NG, Eremkina AK, Mirnaya SS, et al. Joint and muscle involvement in primary hyperparathyroidism. Osteoporosis and bone diseases. 2018;21(4):10-18. (In Russ.) doi: https://doi.org/10.14341/osteo9783
8. Zakirov FN, Krasilnikov AA, Lubyshev EA, Chubanova GR. Perspectives of usage osteoporosis biomarkers in diagnostics and treatment. Surgical practice. 2019;(1):45-47. (In Russ.). doi: https://doi.org/10.17238/issn2223-2427.2019.1.45-47
9. Dobreva EA, Bibik EE, Eremkina AK, et al. Dynamic changes of renin-angiotensin-aldosterone system parameters after surgery of primary hyperparathyroidism. Therapeutic Archive. 2020; 92 (10): 63–69. (In Russ.) doi: https://doi.org/10.26442/00403660.2020.10.000725
10. Dobreva EA, Bibik EE, Eremkina AK, Rebrova OYu, Nikankina LV, Malysheva NM, Mokrysheva NG. Correlations between parameters of calcium metabolism and renin-angiotensin-aldosterone system in patient s with primary hyperparathyroidism in the preand early postoperative periods. Arterial’naya Gipertenziya = Arterial Hypertension. 2019;25(6):630–638. (In Russ.) doi: https://doi.org/10.18705/1607419X-2019-25-6-630-638
11. Bibik EЕ, Eremkina AК, Krupinova JА, Dobreva EА, Mokrysheva NG. Impaired glucose metabolism and other metabolic disorders in patients with primary hyperparathyroidism. Diabetes Mellitus. 2020;23(5):459-466. (In Russ.) doi: https://doi.org/10.14341/DM12436
12. Babinsky VN, Hannan FM, Ramracheya RD et al. Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy. Endocrinology. 2017;158(8):2486-2502. doi: https://doi.org/10.1210/en.2017-00111
13. Slashchuk KY, Degtyarev MV, Rumyantsev PO, et al. Imaging methods of the parathyroid glands in primary hyperparathyroidism. Literature review. Endocrine surgery. 2019;13(4): 153-174. (In Russ.). doi: https://doi.org/10.14341/serg12241
14. Khalaf SH, Sarwani AA, George SM, Al Saeed MK. Primary hyperparathyroidism caused by an ectopic parathyroid adenoma in an uncommon location: a case report. J Taibah Univ Med Sc 2021;16(5):782e787. doi: https://doi.org/10.1016/j.jtumed.2021.02.010
15. Topolnitskiy EB, Borodina YuA. Videothoracoscopic interventions for tumors and cysts of the mediastinum. Endoscopic Surgery. 2020;26(6):17-21. (In Russ.). doi: https://doi.org/10.17116/endoskop20202606117
16. Yablonsky PK, Kuzmichev AS, Shepichev EV, Akinchev AL, Matveeva ZS. Robotic thoracoscopicmparathyroidectomy for ectopic mediastinal parathyroidmadenoma. Grekov’s Bulletin of Surgery. 2021;180(1):89–93. (In Russ.) doi: https://doi.org/10.24884/0042-4625-2021-180-1-89-93
17. Topol’nitskiy EB, Dambaev GTs, Shefer NA, Khodorenko VN, Gunther VE. Replacement of circular defects of the trachea by a flap autopartage in combination with Nickel-titanium mesh (experimental study). Vestnik of new medical technologies. 2012;XIX(3):97–99 (In Russ.).
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Topolnitskiy Y.B., Milovanova T.A., Apalkov D.G., Bibik Е.Е., Goncharova A.I., Tsvetukhin M.O. Primary hyperparathyroidism caused by an ectopic parathyroid adenoma in the mediastinum (case report). Endocrine Surgery. 2024;18(3):36-42. (In Russ.) https://doi.org/10.14341/serg12840
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