Laparoscopic distal pancreatectomy in 16 years girl with insulinoma
Yury Y. Sokolov,
Mariya A. Melikyan,
Sergey A. Karpachev,
Vladimir R. Druzhinin,
Ekaterina A. Tashirova,
Dmitry N. Brovin,
Oleg S. Danilenko https://doi.org/10.14341/serg2016326-32
Abstract
We present a clinical case of insulinoma in 16 years-old girl. The patient complained about episodes of loss of consciousness, followed by retrograde amnesia and accompanied by weakness and dizziness. The patient was transferred to the Department of Endocrinology, where hypoglycemia was detected (2.0-2.5 mmol/l). Topical diagnosis of insulinoma was evidentiated with the help of radiological methods - multislice CT and contrast-enhanced MRI, which revealed an oval tumor 12x10 mm. The molecular genetic analysis of MEN1 gene was performed – no mutations were revealed. Prescribed Proglikem (diazoxide) therapy (100 mg / day) on pre-operative period was effective, patient`s glycemia values stabilized. Further the laparoscopic distal pancreatectomy with tumor removal was performed. After the surgery we achieved stable euglycemia. On microscopic and immunohistochemical studies pancreatic neuroendocrine tumor G1 was confirmed. The discussion presents data on the epidemiology, diagnosis and surgical treatment of insulinomas in children and adults.
About the Authors
Yury Y. Sokolov
Russian Medical Academy of Postgraduate Education
Russian Federation
MD, PhD, Professor
Russian Federation
MD, PhD, Professor
Mariya A. Melikyan
Endocrinology Research Centre
Russian Federation
MD, PhD
Russian Federation
MD, PhD
Sergey A. Karpachev
Endocrinology Research Centre
Russian Federation
MD
Russian Federation
MD
Vladimir R. Druzhinin
Pediatric City Clinical Hospital named after Z.A. Bashlyaeva
Russian Federation
MD
Russian Federation
MD
Ekaterina A. Tashirova
Pediatric City Clinical Hospital named after Z.A. Bashlyaeva
Russian Federation
MD
Russian Federation
MD
Dmitry N. Brovin
Endocrinology Research Centre
Russian Federation
MD
Russian Federation
MD
Oleg S. Danilenko
Endocrinology Research Centre
Russian Federation
MD
Russian Federation
MD
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Review
For citations:
Sokolov Yu.Y., Melikyan M.A., Karpachev S.A., Druzhinin V.R., Tashirova E.A., Brovin D.N., Danilenko O.S. Laparoscopic distal pancreatectomy in 16 years girl with insulinoma. Endocrine Surgery. 2016;10(3):26-32. (In Russ.) https://doi.org/10.14341/serg2016326-32
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