2017 Russian clinical practice guidelines for differentiated thyroid cancer diagnosis and treatment
https://doi.org/10.14341/serg201716-27
Abstract
The Russian clinical practice guidelines for diagnosis and treatment of differentiated thyroid cancer is dedicated to the management of patients with differentiated thyroid cancer. The guideline modifications 2016 include the following matters: indication for fine-needle aspiration biopsy, calcitonin screening, standards for biopsy results, new positions of postoperative risk stratification, indication for suppressive therapy and thyroid replacement therapy, targeted therapy in patients with radioiodine-refractory differentiated thyroid cancer.
About the Authors
Dmitriy G. BeltsevichEndocrinology Research Centre
Russian Federation
MD, PhD Professor
Competing Interests:
No conflict of interest
Vladimir E. Vanushko
Endocrinology Research Centre
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Pavel O. Rumiantsev
Endocrinology Research Centre
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Galina A. Melnichenko
Endocrinology Research Centre; I.M. Sechenov First Moscow State Medical University
Russian Federation
MD, PhD, Professor
Competing Interests:
Конфликт интересов отсутствует.
Nikolay S. Kuznetsov
Endocrinology Research Centre
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Aleksandr Yu. Abrosimov
Endocrinology Research Centre
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Vladimir G. Polyakov
N.N. Blokhin Russian Cancer Research Center
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Ali M. Mudunov
N.N. Blokhin Russian Cancer Research Center
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Sergey O. Podvyaznikov
Russian Medical Academy of Continuous Professional Education
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Ilja S. Romanov
N.N. Blokhin Russian Cancer Research Center; The Russian National Research Medical University named after N.I. Pirogov
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Andrey P. Polyakov
National Medical Research Radiological Centre
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Ilja V. Sleptsov
National Medical Surgery Center named after N.I. Pirogov; Saint-Petersburg Multiprofile Medical Center
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Roman A. Chernikov
Saint-Petersburg Multiprofile Medical Center
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Sergey L. Vorobyov
Saint-Petersburg Multiprofile Medical Center
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
Valentin V. Fadeyev
I.M. Sechenov First Moscow State Medical University
Russian Federation
MD, PhD
Competing Interests:
Конфликт интересов отсутствует.
References
1. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid.2015;26(1):1-133. doi: 10.1089/thy.2015.0020.
2. Cooper DS, Doherty GM, Haugen BR, et al. Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid.2009;19(11):1167-1214. doi: 10.1089/thy.2009.0110.
3. Charkes ND. On the prevalence of familial nonmedullary thyroid cancer in multiply affected kindreds. Thyroid. 2006;16:181-186. doi: 10.1089/thy.2006.16.181.
4. Capezzone M, Marchisotta S, Cantara S, et al. Familial non-medullary thyroid carcinoma displays the features of clinical anticipation suggestive of a distinct biological entity. Endocr Relat Cancer. 2008;15(4):1075-1081. doi: 10.1677/ERC-08-0080.
5. Moses W, Weng J, Kebebew E. Prevalence, clinicopathologic features, and somatic genetic mutation profile in familial versus sporadic nonmedullary thyroid cancer. Thyroid. 2011;21(4):367-371. doi: 10.1089/thy.2010.0256.
6. Ito Y, Kakudo K, Hirokawa M, et al. Biological behavior and prognosis of familial papillary thyroid carcinoma. Surgery. 2009;145(1):100-105. doi: 10.1016/j.surg.2008.08.004.
7. Park YJ, Ahn HY, Choi HS, et al. The long-term outcomes of the second generation of familial nonmedullary thyroid carcinoma are more aggressive than sporadic cases. Thyroid. 2012;22(4):356-362. doi: 10.1089/thy.2011.0163.
8. Mazeh H, Benavidez J, Poehls JL, et al. In patients with thyroid cancer of follicular cell origin, a family history of nonmedullary thyroid cancer in one first-degree relative is associated with more aggressive disease. Thyroid. 2012;22(1):3-8. doi: 10.1089/thy.2011.0192.
9. Robenshtok E, Tzvetov G, Grozinsky-Glasberg S, et al. Clinical characteristics and outcome of familial nonmedullary thyroid cancer: a retrospective controlled study. Thyroid. 2011;21(1):43-48. doi: 10.1089/thy.2009.0406.
10. Richards ML. Familial syndromes associated with thyroid cancer in the era of personalized medicine. Thyroid. 2010;20(7):707-713. doi: 10.1089/thy.2010.1641.
11. Elisei R, Bottici V, Luchetti F, et al. Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders. J Clin Endocrinol Metab. 2004;89(1):163-168. doi: 10.1210/jc.2003-030550.
12. Hahm JR, Lee MS, Min YK, et al. Routine measurement of serum calcitonin is useful for early detection of medullary thyroid carcinoma in patients with nodular thyroid diseases. Thyroid. 2001;11(1):73-80. doi: 10.1089/10507250150500694.
13. Niccoli P, Wion-Barbot N, Caron P, et al. Interest of routine measurement of serum calcitonin: study in a large series of thyroidectomized patients. The French Medullary Study Group. J Clin Endocrinol Metab. 1997;82:338-341. doi: 10.1210/jcem.82.2.3737.
14. Costante G, Meringolo D, Durante C, et al. Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. J Clin Endocrinol Metab. 2007;92(2):450-455. doi: 10.1210/jc.2006-1590.
15. Chambon G, Alovisetti C, Idoux-Louche C, et al. The use of preoperative routine measurement of basal serum thyrocalcitonin in candidates for thyroidectomy due to nodular thyroid disorders: results from 2733 consecutive patients. J Clin Endocrinol Metab. 2011;96(1):75-81. doi: 10.1210/jc.2010-0162.
16. Абдулхабирова Ф.М., Бельцевич Д.Г., Ванушко В.Э., и др. Диагностика и лечение медуллярного рака щитовидной железы (проект национальных клинических рекомендаций). // Эндокринная хирургия. – 2012. – Т. 6. – №1 – С. 5–17. [Abdulkhabirova FM, Bel'tsevich DG, Vanushko VE, et al. Medullary Thyroid Cancer: Management Guidelines. Endocrine Surgery. 2012;6(1):5-17. (in Russ.)] doi: 10.14341/2306-3513-2012-1-5-17.
17. Repplinger D, Bargren A, Zhang YW, et al. Is Hashimoto’s thyroiditis a risk factor for papillary thyroid cancer? J Surg Res. 2008;150(1):49-52. doi: 10.1016/j.jss.2007.09.020.
18. Suh I, Vriens MR, Guerrero MA, et al. Serum thyroglobulin is a poor diagnostic biomarker of malignancy in follicular and Hurthle-cell neoplasms of the thyroid. Am J Surg. 2010;200(1):41-46. doi: 10.1016/j.amjsurg.2009.08.030.
19. Lee EK, Chung KW, Min HS, et al. Preoperative serum thyroglobulin as a useful predictive marker to differentiate follicular thyroid cancer from benign nodules in indeterminate nodules. J Korean Med Sci. 2012;27(9):1014-1018. doi: 10.3346/jkms.2012.27.9.1014.
20. Smith-Bindman R, Lebda P, Feldstein VA, et al. Risk of thyroid cancer based on thyroid ultrasound imaging characteristics: results of a population-based study. JAMA Intern Med. 2013;173(19):1788-1796. doi: 10.1001/jamainternmed.2013.9245.
21. Brito JP, Gionfriddo MR, Al Nofal A, et al. The accuracy of thyroid nodule ultrasound to predict thyroid cancer: systematic review and meta-analysis. J Clin Endocrinol Metab. 2014;99(4):1253-1263. doi: 10.1210/jc.2013-2928.
22. Langer JE, Agarwal R, Zhuang H, et al. Correlation of findings from iodine 123 scan and ultrasonography in the recommendation for thyroid fine needle aspiration biopsy. Endocr Pract. 2011;17(5):699-706. doi: 10.4158/EP10382.OR.
23. Kwak JY, Han KH, Yoon JH, et al. Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk. Radiology. 2011;260(3):892-899. doi: 10.1148/radiol.11110206.
24. Moon WJ, Jung SL, Lee JH, et al. Benign and malignant thyroid nodules: US differentiation –multicenter retrospective study. Radiology. 2008;247(3):762-770. doi: 10.1148/radiol.2473070944.
25. Moon HJ, Kwak JY, Kim MJ, et al. Can vascularity at power Doppler US help predict thyroid malignancy? Radiology. 2010;255(1):260-269. doi: 10.1148/radiol.09091284.
26. Salmaslioglu A, Erbil Y, Dural C, et al. Predictive value of sonographic features in preoperative evaluation of malignant thyroid nodules in a multinodular goiter. World J Surg. 2008;32(9):1948-1954. doi: 10.1007/s00268-008-9600-2.
27. Papini E, Guglielmi R, Bianchini A, et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab. 2002;87(5):1941-1946. doi: 10.1210/jcem.87.5.8504.
28. Gul K, Ersoy R, Dirikoc A, et al. Ultrasonographic evaluation of thyroid nodules: comparison of ultrasonographic, cytological, and histopathological findings. Endocrine. 2009;36(3):464-472. doi: 10.1007/s12020-009-9262-3.
29. Cappelli C, Pirola I, Cumetti D, et al. Is the anteroposterior and transverse diameter ratio of nonpalpable thyroid nodules a sonographic criteria for recommending fine-needle aspiration cytology? Clin Endocrinol (Oxf). 2005;63(6):689-693. doi: 10.1111/j.1365-2265.2005.02406.x.
30. Frates MC, Benson CB, Doubilet PM, et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab. 2006;91(9):3411-3417. doi: 10.1210/jc.2006-0690.
31. Horvath E, Majlis S, Rossi R, et al. An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. J Clin Endocrinol Metab. 2009;94(5):1748-1751. doi: 10.1210/c.2008-1724.
32. Tae HJ, Lim DJ, Baek KH, et al. Diagnostic value of ultrasonography to distinguish between benign and malignant lesions in the management of thyroid nodules. Thyroid. 2007;17(5):461-466. doi: 10.1089/thy.2006.0337.
33. Shimura H, Haraguchi K, Hiejima Y, et al. Distinct diagnostic criteria for ultrasonographic examination of papillary thyroid carcinoma: a multicenter study. Thyroid. 2005;15(3):251-258. doi: 10.1089/thy.2005.15.251.
34. Russ G, Royer B, Bigorgne C, et al. Prospective evaluation of thyroid imaging reporting and data system on 4550 nodules with and without elastography. Eur J Endocrinol. 2013;168(5):649-655. doi: 10.1530/EJE-12-0936.
35. Cheng SP, Lee JJ, Lin JL, et al. Characterization of thyroid nodules using the proposed thyroid imaging reporting and data system (TIRADS). Head Neck. 2013;35(4):541-547. doi: 10.1002/hed.22985.
36. Ito Y, Amino N, Yokozawa T, et al. Ultrasonographic evaluation of thyroid nodules in 900 patients: comparison among ultrasonographic, cytological, and histological findings. Thyroid. 2007;17(12):1269-1276. doi: 10.1089/thy.2007.0014.
37. Ito Y, Miyauchi A, Kihara M, et al. 2014 Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation. Thyroid. 2014;24(1):27-34. doi: 10.1089/thy.2013.0367.
38. Baloch ZW, LiVolsi VA, Asa SL, et al. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol. 2008;36(6):425-437. doi: 10.1002/dc.20830.
39. Crippa S, Mazzucchelli L, Cibas ES, et al. The Bethesda System for reporting thyroid fine-needle aspiration specimens. Am J Clin Pathol. 2010;134(2):343-344. doi: 10.1309/ajcpxm9wirq8jzbj.
40. Na DG, Kim JH, Sung JY, et al. Core-needle biopsy is more useful than repeat fine-needle aspiration in thyroid nodules read as nondiagnostic or atypia of undetermined significance by the Bethesda System for reporting thyroid cytopathology. Thyroid. 2012;22(5):468-475. doi: 10.1089/thy.2011.0185.
41. Nam SY, Han BK, Ko EY, et al. BRAFV600E mutation analysis of thyroid nodules needle aspirates in relation to their ultrasongraphic classification: a potential guide for selection of samples for molecular analysis. Thyroid. 2010;20(3):273-279. doi: 10.1089/thy.2009.0226.
42. Yip L, Nikiforova MN, Carty SE, et al. Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation. Surgery. 2009;146(6):1215-1223. doi: 10.1016/j.surg.2009.09.011.
43. Cantara S, Capezzone M, Marchisotta S, et al. Impact of proto-oncogene mutation detection in cytological specimens from thyroid nodules improves the diagnostic accuracy of cytology. J Clin Endocrinol Metab. 2010;95(3):1365-1369. doi: 10.1210/jc.2009-2103.
44. Renshaw AA, Pinnar N. Comparison of thyroid fine-needle aspiration and core needle biopsy. Am J Clin Pathol. 2007;128(3):370-374. doi: 10.1309/07TL3V58337TXHMC.
45. Yeon JS, Baek JH, Lim HK, et al. Thyroid nodules with initially nondiagnostic cytologic results: the role of core-needle biopsy. Radiology. 2013;268(1):274-280. doi: 10.1148/radiol.13122247.
46. Ahn JE, Lee JH, Yi JS, et al. Diagnostic accuracy of CT and ultrasonography for evaluating metastatic cervical lymph nodes in patients with thyroid cancer. World J Surg. 2008;32(7):1552-1558. doi: 10.1007/s00268-008-9588-7.
47. Choi JS, Kim J, Kwak JY, et al. Preoperative staging of papillary thyroid carcinoma: comparison of ultrasound imaging and CT. AJR Am J Roentgenol. 2009;193(3):871-878. doi: 10.2214/AJR.09.2386.
48. Lesnik D, Cunnane ME, Zurakowski D, et al. Papillary thyroid carcinoma nodal surgery directed by a preoperative radiographic map utilizing CT scan and ultrasound in all primary and reoperative patients. Head Neck. 2014;36(2):191-202. doi: 10.1002/hed.23277.
49. Jeong HS, Baek CH, Son YI, et al. Integrated 18F-FDG PET/CT for the initial evaluation of cervical node level of patients with papillary thyroid carcinoma: comparison with ultrasound and contrast-enhanced CT. Clin Endocrinol (Oxf). 2006;65(3):402-407. doi: 10.1111/j.1365-2265.2006.02612.x.
50. Kaplan SL, Mandel SJ, Muller R, et al. The role of MR imaging in detecting nodal disease in thyroidectomy patients with rising thyroglobulin levels. AJNR Am J Neuroradiol. 2009;30(3):608-661. doi: 10.3174/ajnr.A1405.
51. Andersen PE, Kinsella J, Loree TR, et al. Differentiated carcinoma of the thyroid with extrathyroidal extension. Am J Surg. 1995;170(5):467-470. doi: 10.1016/S0002-9610(99)80331-6.
52. Kim E, Park JS, Son KR, et al. Preoperative diagnosis of cervical metastatic lymph nodes in papillary thyroid carcinoma: comparison of ultrasound, computed tomography, and combined ultrasound with computed tomography. Thyroid. 2008;18(4):411-418. doi: 10.1089/thy.2007.0269.
53. Yeh MW, Bauer AJ, Bernet VA, et al. American Thyroid Association statement on preoperative imaging for thyroid cancer surgery. Thyroid. 2015;25(1):3-14. doi: 10.1089/thy.2014.0096.
54. Sosa JA, Bowman HM, Tielsch JM, et al. The importance of surgeon experience for clinical and economic outcomes from thyroidectomy. Ann Surg. 1998;228(3):320-330. doi: 10.1097/00000658-199809000-00005.
55. Loyo M, Tufano RP, Gourin CG. National trends in thyroid surgery and the effect of volume on short-term outcomes. Laryngoscope. 2013;123(8):2056-2063. doi: 10.1002/lary.23923.
56. Gourin CG, Tufano RP, Forastiere AA, et al. Volume-based trends in thyroid surgery. Arch Otolaryngol Head Neck Surg. 2010;136(12):1191-1198. doi: 10.1001/archoto.2010.212.
57. Stavrakis AI, Ituarte PH, Ko CY, et al. Surgeon volume as a predictor of outcomes in inpatient and outpatient endocrine surgery. Surgery. 2007;142(6):887-899. doi: 10.1016/j.surg.2007.09.003.
58. Bilimoria KY, Bentrem DJ, Ko CY, et al. Extent of surgery affects survival for papillary thyroid cancer. Ann Surg. 2007;246(3):375-381. doi: 10.1097/SLA.0b013e31814697d9.
59. Grant CS, Hay ID, Gough IR, et al. Local recurrence in papillary thyroid carcinoma: is extent of surgical resection important? Surgery. 1988;104(6):954-962.
60. Hay ID, Grant CS, Bergstralh EJ, et al. Unilateral total lobectomy: is it sufficient surgical treatment for patients with AMES low-risk papillary thyroid carcinoma? Surgery. 1998;124(6):958-964. doi: 10.1016/S0039-6060(98)70035-2.
61. Mazzaferri EL, Kloos RT. Clinical review 128: Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab. 2001;86(4):1447-1463. doi: 10.1210/jcem.86.4.7407.
62. Matsuzu K, Sugino K, Masudo K, et al. Thyroid lobectomy for papillary thyroid cancer: long-term follow-up study of 1,088 cases. World J Surg. 2014;38(1):68-79. doi: 10.1007/s00268-013-2224-1.
63. Barney BM, Hitchcock YJ, Sharma P, et al. Overall and cause-specific survival for patients undergoing lobectomy, near-total, or total thyroidectomy for differentiated thyroid cancer. Head Neck. 2011;33(5):645-649. doi: 10.1002/hed.21504.
64. Mendelsohn AH, Elashoff DA, Abemayor E, et al. Surgery for papillary thyroid carcinoma: is lobectomy enough? Arch Otolaryngol Head Neck Surg. 2010;136(11):1055-1061. doi: 10.1001/archoto.2010.181.
65. Haigh PI, Urbach DR, Rotstein LE. Extent of thyroidectomy is not a major determinant of survival in lowor high-risk papillary thyroid cancer. Ann Surg Oncol. 2005;12(1):81-89. doi: 10.1007/s10434-004-1165-1.
66. Nixon IJ, Ganly I, Patel SG, et al. Thyroid lobectomy for treatment of well differentiated intrathyroid malignancy. Surgery. 2012;151(4):571-579. doi: 10.1016/j.surg.2011.08.016.
67. Adam MA, Pura J, Gu L et al. Extent of surgery for papillary thyroid cancer is not associated with survival: an analysis of 61,775 patients. Ann Surg. 2014;260(4):601-605. doi: 10.1097/SLA.0000000000000925.
68. Vaisman F, Shaha A, Fish S, et al. Initial therapy with either thyroid lobectomy or total thyroidectomy without radioactive iodine remnant ablation is associated with very low rates of structural disease recurrence in properly selected patients with differentiated thyroid cancer. Clin Endocrinol (Oxf).2011;75(1):112-119. doi: 10.1111/j.1365-2265.2011.04002.x.
69. Stulak JM, Grant CS, Farley DR, et al. Value of preoperative ultrasonography in the surgical management of initial and reoperative papillary thyroid cancer. Arch Surg. 2006;141(5):489-494. doi: 10.1001/archsurg.141.5.489.
70. Kouvaraki MA, Shapiro SE, Fornage BD, et al. Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer. Surgery. 2003;134(6):946-954. doi: 10.1016/S0039-6060(03)00424-0.
71. Hughes DT, White ML, Miller BS, et al. Influence of prophylactic central lymph node dissection on postoperative thyroglobulin levels and radioiodine treatment in papillary thyroid cancer. Surgery. 2010;48(6):1100-1106. doi: 10.1016/j.surg.2010.09.019.
72. Randolph GW, Duh QY, Heller KS, et al. The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension. Thyroid. 2012;22(11):1144-1152. doi: 10.1089/thy.2012.0043.
73. Zaydfudim V, Feurer ID, Griffin MR, et al. The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma. Surgery. 2008;144(6):1070-1077. doi: 10.1016/j.surg.2008.08.034.
74. Leboulleux S, Rubino C, Baudin E, et al. Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and/or tumor extension beyond the thyroid capsule at initial diagnosis. J Clin Endocrinol Metab. 2005;90(10):5723-5729. doi: 10.1210/jc.2005-0285.
75. Sugitani I, Kasai N, Fujimoto Y, et al. A novel classification system for patients with PTC: addition of the new variables of large (3 cm or greater) nodal metastases and reclassification during the follow-up period. Surgery. 2004;135(2):139-148. doi: 10.1016/S0039-6060(03)00384-2.
76. Robbins KT, Shaha AR, Medina JE, et al. Consensus statement on the classification and terminology of neck dissection. Arch Otolaryngol Head Neck Surg. 2008;134(5):536-538. doi: 10.1001/archotol.134.5.536.
77. Hwang HS, Orloff LA. Efficacy of preoperative neck ultrasound in the detection of cervical lymph node metastasis from thyroid cancer. Laryngoscope. 2011;121(3):487-491. doi: 10.1002/lary.21227.
78. Mulla M, Schulte KM. Central cervical lymph node metastases in papillary thyroid cancer: a systematic review of imaging-guided and prophylactic removal of the central compartment. Clin Endocrinol (Oxf). 2012;76(1):131-136. doi: 10.1111/j.1365-2265.2011.04162.x.
79. Hartl DM, Leboulleux S, Al Ghuzlan A, et al. Optimization of staging of the neck with prophylactic central and lateral neck dissection for papillary thyroid carcinoma. Ann Surg. 2012;255(4):777-783. doi: 10.1097/SLA.0b013e31824b7b68.
80. Popadich A, Levin O, Lee JC, et al. A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer. Surgery. 2011;150(6):1048-1057. doi: 10.1016/j.surg.2011.09.003.
81. Chisholm EJ, Kulinskaya E, Tolley NS. Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone. Laryngoscope. 2009;119(6):1135-1139. doi: 10.1002/lary.20236.
82. Bonnet S, Hartl D, Leboulleux S, et al. Prophylactic lymph node dissection for papillary thyroid cancer less than 2 cm: implications for radioiodine treatment. J Clin Endocrinol Metab. 2009;94(4):1162-1167. doi: 10.1210/jc.2008-1931.
83. Sancho JJ, Lennard TW, Paunovic I, et al. Prophylactic central neck disection in papillary thyroid cancer: a consensus report of the European Society of Endocrine Surgeons (ESES). Langenbecks Arch Surg. 2014;399(2):155-163. doi: 10.1007/s00423-013-1152-8.
84. Zetoune T, Keutgen X, Buitrago D, et al. Prophylactic central neck dissection and local recurrence in papillary thyroid cancer: a meta-analysis. Ann Surg Oncol. 2010;17(12):3287-3293. doi: 10.1245/s10434-010-1137-6.
85. Barczynski M, Konturek A, Stopa M, et al. Prophylactic central neck dissection for papillary thyroid cancer. Br J Surg. 2013;100(3):410-418. doi: 10.1002/bjs.8985.
86. Hartl DM, Mamelle E, Borget I, et al. Influence of prophylactic neck dissection on rate of retreatment for papillary thyroid carcinoma. World J Surg. 2013;37(8):1951-1958. doi: 10.1007/s00268-013-2089-3.
87. Sywak M, Cornford L, Roach P, et al. Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid cancer. Surgery. 2006;140(6):1000-1005. doi: 10.1016/j.surg.2006.08.001.
88. Laird AM, Gauger PG, Miller BS, et al. Evaluation of postoperative radioactive iodine scans in patients who underwent prophylactic central lymph node dissection. World J Surg. 2012;36(6):1268-1273. doi: 10.1007/s00268-012-1431-5.
89. Costa S, Giugliano G, Santoro L, et al. Role of prophylactic central neck dissection in cN0 papillary thyroid cancer. Acta Otorhinolaryngol Ital. 2009;29(2):61-69.
90. Ryu IS, Song CI, Choi SH, et al. Lymph node ratio of the central compartment is a significant predictor for locoregional recurrence after prophylactic central neck dissection in patients with thyroid papillary carcinoma. Ann Surg Oncol. 2014;21(1):277-283. doi: 10.1245/s10434-013-3258-1.
91. Moreno MA, Edeiken-Monroe BS, Siegel ER, et al. In papillary thyroid cancer, preoperative central neck ultrasound detects only macroscopic surgical disease, but negative findings predict excellent long-term regional control and survival. Thyroid. 2012;22(4):347-355. doi: 10.1089/thy.2011.0121.
92. Yoo D, Ajmal S, Gowda S, et al. Level VI lymph node dissection does not decrease radioiodine uptake in patients undergoing radioiodine ablation for differentiated thyroid cancer. World J Surg. 2012;36(6):1255-1261. doi: 10.1007/s00268-012-1507-2.
93. Roh JL, Park JY, Park CI. Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone. Ann Surg. 2007;245(4):604-610. doi: 10.1097/01.sla.0000250451.59685.67.
94. Cavicchi O, Piccin O, Caliceti U, et al. Transient hypoparathyroidism following thyroidectomy: a prospective study and multivariate analysis of 604 consecutive patients. Otolaryngol Head Neck Surg. 2007;137(4):654-658. doi: 10.1016/j.otohns.2007.03.001.
95. Raffaelli M, De Crea C, Sessa L, et al. Prospective evaluation of total thyroidectomy versus ipsilateral versus bilateral central neck dissection in patients with clinically node-negative papillary thyroid carcinoma. Surgery. 2012;152(6):957-964. doi: 10.1016/j.surg.2012.08.053.
96. Viola D, Materazzi G, Valerio L, et al. Prophylactic central compartment lymph node dissection in papillary thyroid carcinoma: clinical implications derived from the first prospective randomized controlled single institution study. J Clin Endocrinol Metab. 2015;100(4):1316-1324. doi: 10.1210/jc.2014-3825.
97. Nikiforova MN, Kimura ET, Gandhi M, et al. BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab. 2003;88(11):5399-5404. doi: 10.1210/jc.2003-030838.
98. Hawk WA, Hazard JB. The many appearances of papillary carcinoma of the thyroid. Cleve Clin Q. 1976;43(4):207-215.
99. Leung AK, Chow SM, Law SC. Clinical features and outcome of the tall cell variant of papillary thyroid carcinoma. Laryngoscope. 2008;118(1):32-38. doi: 10.1097/MLG.0b013e318156f6c3.
100. Moreno EA, Rodriguez Gonzalez JM, Sola PJ, et al. Prognostic value of the tall cell variety of papillary cancer of the thyroid. Eur J Surg Oncol. 1993;19(6):517-521.
101. Johnson TL, Lloyd RV, Thompson NW, et al. Prognostic implications of the tall cell variant of papillary thyroid carcinoma. Am J Surg Pathol. 1988;12(1):22-27.
102. Michels JJ, Jacques M, Henry-Amar M, et al. Prevalence and prognostic significance of tall cell variant of papillary thyroid carcinoma. Hum Pathol. 2007;38(2):212-219. doi: 10.1016/j.humpath.2006.08.001.
103. Asioli S, Erickson LA, Sebo TJ, et al. Papillary thyroid carcinoma with prominent hobnail features: a new aggressive variant of moderately differentiated papillary carcinoma. A clinicopathologic, immunohistochemical, and molecular study of eight cases. Am J Surg Pathol. 2010;34(1):44-52. doi: 10.1097/PAS.0b013e3181c46677.
104. Motosugi U, Murata S, Nagata K, et al. Thyroid papillary carcinoma with micropapillary and hobnail growth pattern: a histological variant with intermediate malignancy? Thyroid. 2009;19(5):535-537. doi: 10.1089/thy.2008.0271.
105. Lubitz CC, Economopoulos KP, Pawlak AC, et al. Hobnail variant of papillary thyroid carcinoma: an institutional case series and molecular profile. Thyroid. 2014;24(6):958-965. doi: 10.1089/thy.2013.0573.
106. Sherman SI. Toward a standard clinicopathologic staging approach for differentiated thyroid carcinoma. Semin Surg Oncol. 1999;16(1):12-15.
107. Onitilo AA, Engel JM, Lundgren CI, et al. Simplifying the TNM system for clinical use in differentiated thyroid cancer. J Clin Oncol. 2009;27(11):1872-1878. doi: 10.1200/JCO.2008.20.2382.
108. Mankarios D, Baade P, Youl P, et al. Validation of the QTNM staging system for cancer-specific survival in patients with differentiated thyroid cancer. Endocrine. 2014;46(2):300-308. doi: 10.1007/s12020-013-0078-9.
109. Edmonds CJ, Hayes S, Kermode JC, et al. Measurement of serum TSH and thyroid hormones in the management of treatment of thyroid carcinoma with radioiodine. Br J Radiol. 1977;50(599):799-807. doi: 10.1259/0007-1285-50-599-799.
110. Leboeuf R, Perron P, Carpentier AC, et al. L-T3 preparation for whole-body scintigraphy: a randomized-controlled trial. Clin Endocrinol (Oxf). 2007;67(6):839-844. doi: 10.1111/j.1365-2265.2007.02972.x.
111. Lee J, Yun MJ, Nam KH, et al. Quality of life and effectiveness comparisons of thyroxine withdrawal, triiodothyronine withdrawal, and recombinant thyroid-stimulating hormone administration for low-dose radioiodine remnant ablation of differentiated thyroid carcinoma. Thyroid. 2010;20(2):173-179. doi: 10.1089/thy.2009.0187.
112. Fallahi B, Beiki D, Takavar A, et al. Low versus high radioiodine dose in postoperative ablation of residual thyroid tissue in patients with differentiated thyroid carcinoma: a large randomized clinical trial. Nucl Med Commun. 2012;33(3):275-282. doi: 10.1097/MNM.0b013e32834e306a.
113. Robbins RJ, Driedger A, Magner J. Recombinant human thyrotropin-assisted radioiodine therapy for patients with metastatic thyroid cancer who could not elevate endogenous thyrotropin or be withdrawn from thyroxine. Thyroid. 2006;16(11):1121-1130. doi: 10.1089/thy.2006.16.1121.
114. Chianelli M, Todino V, Graziano FM, et al. Low-activity (2.0 GBq; 54 mCi) radioiodine post-surgical remnant ablation in thyroid cancer: comparison between hormone withdrawal and use of rhTSH in low-risk patients. Eur J Endocrinol. 2009;160(3):431-436. doi: 10.1530/EJE-08-0669.
115. Mallick U, Harmer C, Yap B, et al. Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer. N Engl J Med. 2012;366(18):1674-1685. doi: 10.1056/NEJMoa1109589.
116. Pacini F, Ladenson PW, Schlumberger M, et al. Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study. J Clin Endocrinol Metab. 2006;91(3):926-932. doi: 10.1210/jc.2005-1651.
117. Schlumberger M, Catargi B, Borget I, et al. Strategies of radioiodine ablation in patients with low-risk thyroid cancer. N Engl J Med. 2012;366:1663-1673. doi: 10.1056/NEJMoa1108586.
118. Taieb D, Sebag F, Cherenko M, et al. Quality of life changes and clinical outcomes in thyroid cancer patients undergoing radioiodine remnant ablation (RRA) with recombinant human TSH (rhTSH): a randomized controlled study. Clin Endocrinol (Oxf). 2009;71(1):115-123. doi: 10.1111/j.1365-2265.2008.03424.x.
119. Emmanouilidis N, Muller JA, Jager MD, et al. Surgery and radioablation therapy combined: introducing a 1-week condensed procedure bonding total thyroidectomy and radioablation therapy with recombinant human TSH. Eur J Endocrinol. 2009;161(5):763-769. doi: 10.1530/EJE-08-0641.
120. Tu J, Wang S, Huo Z, et al. Recombinant human thyrotropin-aided versus thyroid hormone withdrawal-aided radioiodine treatment for differentiated thyroid cancer after total thyroidectomy: a meta-analysis. Radiother Oncol. 2014;110(1):25-30. doi: 10.1016/j.radonc.2013.12.018.
121. Pak K, Cheon GJ, Kang KW, et al. The effectiveness of recombinant human thyroid-stimulating hormone versus thyroid hormone withdrawal prior to radioiodine remnant ablation in thyroid cancer: a meta-analysis of randomized controlled trials. J Korean Med Sci. 2014;29(6):811-817. doi: 10.3346/jkms.2014.29.6.811.
122. Elisei R, Schlumberger M, Driedger A, et al. Follow-up of low-risk differentiated thyroid cancer patients who underwent radioiodine ablation of postsurgical thyroid remnants after either recombinant human thyrotropin or thyroid hormone withdrawal. J Clin Endocrinol Metab. 2009;94(11):4171-4179. doi: 10.1210/jc.2009-0869.
123. Emmanouilidis N, Schrem H, Winkler M, et al. Long-term results after treatment of very low-, low-, and high-risk thyroid cancers in a combined setting of thyroidectomy and radio ablation therapy in euthyroidism. Int J Endocrinol. 2013:769473. doi: 10.1155/2013/769473.
124. Hugo J, Robenshtok E, Grewal R, et al. Recombinant human thyroid stimulating hormoneassisted radioactive iodine remnant ablation in thyroid cancer patients at intermediate to high risk of recurrence. Thyroid. 2012;22(10):1007-1015. doi: 10.1089/thy.2012.0183.
125. Rosario PW, Mineiro Filho AF, Lacerda RX, et al. Long-term follow-up of at least five years after recombinant human thyrotropin compared to levothyroxine withdrawal for thyroid remnant ablation with radioactive iodine. Thyroid. 2012;22(3):332-323. doi: 10.1089/thy.2011.0242.
126. Maenpaa HO, Heikkonen J, Vaalavirta L, et al. Low vs. high radioiodine activity to ablate the thyroid after thyroidectomy for cancer: a randomized study. PLoS One. 2008;3(4):e1885. doi: 10.1371/journal.pone.0001885.
127. Pilli T, Brianzoni E, Capoccetti F, et al. A comparison of 1850 (50 mCi) and 3700MBq (100 mCi) 131-iodine administered doses for recombinant thyrotropin-stimulated postoperative thyroid remnant ablation in differentiated thyroid cancer. J Clin Endocrinol Metab. 2007;92(9):3542-6. doi: 10.1210/jc.2007-0225.
128. Zaman M, Toor R, Kamal S, et al. A randomized clinical trial comparing 50mCi and 100mCi of iodine-131 for ablation of differentiated thyroid cancers. J Pak Med Assoc. 2006;56(8):353-356.
129. Kukulska A, Krajewska J, Gawkowska-Suwinska M, et al. Radioiodine thyroid remnant ablation in patients with differentiated thyroid carcinoma (DTC): prospective comparison of long-term outcomes of treatment with 30, 60 and 100 mCi. Thyroid Res. 2010;3(1):9. doi: 10.1186/1756-6614-3-9.
130. Castagna MG, Cevenini G, Theodoropoulou A, et al. Post-surgical thyroid ablation with low or high radioiodine activities results in similar outcomes in intermediate risk differentiated thyroid cancer patients. Eur J Endocrinol. 2013;169(1):23-29. doi: 10.1530/EJE-12-0954.
131. Han JM, Kim WG, Kim TY, et al. Effects of low-dose and high-dose postoperative radioiodine therapy on the clinical outcome in patients with small differentiated thyroid cancer having microscopic extrathyroidal extension. Thyroid. 2014;24(5):820-825. doi: 10.1089/thy.2013.0362.
132. Kruijff S, Aniss AM, Chen P, et al. Decreasing the dose of radioiodine for remnant ablation does not increase structural recurrence rates in papillary thyroid carcinoma. Surgery. 2013;154(6):1337-1344. doi: 10.1016/j.surg.2013.06.034.
133. Sabra M, Grewal R, Ghossein RM, et al. Higher administered activities of radioactive iodine are associated with less structural persistent response in older, but not younger, papillary thyroid cancer patients with lateral neck lymph node metastases. Thyroid. 2014;24(7):1088-1095. doi: 10.1089/thy.2013.0465.
134. Tuttle RM, Tala H, Shah J, et al. Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system. Thyroid.2010;20(12):1341-1349. doi: 10.1089/thy.2010.0178.
135. Vaisman F, Momesso D, Bulzico DA, et al. Spontaneous remission in thyroid cancer patients after biochemical incomplete response to initial therapy. Clin Endocrinol (Oxf). 2012;77(1):132-138. doi: 10.1111/j.1365-2265.2012.04342.x.
136. Tuttle RM, Leboeuf R. Follow up approaches in thyroid cancer: a risk adapted paradigm. Endocrinol Metab Clin North Am. 2008;37(2):419-435. doi: 10.1016/j.ecl.2008.02.008.
137. Momesso DP, Tuttle RM. Update on differentiated thyroid cancer staging. Endocrinol Metab Clin North Am. 2014;43(2):401-421. doi: 10.1016/j.ecl.2014.02.010.
138. Cooper DS, Specker B, Ho M, et al. Thyrotropin suppression and disease progression in patients with differentiated thyroid cancer: results from the National Thyroid Cancer Treatment Cooperative Registry. Thyroid. 1998;8(9):737-744. doi: 10.1089/thy.1998.8.737.
139. Bilimoria KY, Bentrem DJ, Ko CY, et al. Extent of surgery affects survival for papillary thyroid cancer. Ann Urg. 2007;246(3):375-384. doi: 10.1097/SLA.0b013e31814697d9.
140. Barney BM, Hitchcock YJ, Sharma P, et al. Overall and cause-specific survival for patients undergoing lobectomy, near-total, or total thyroidectomy for differentiated thyroid cancer. Head Neck. 2011;33(5):645-649. doi: 10.1002/hed.21504.
141. Mendelsohn AH, Elashoff DA, Abemayor E, et al. Surgery for papillary thyroid carcinoma: is lobectomy enough? Arch Otolaryngol Head Neck Surg. 2010;136(11):1055-1061. doi: 10.1001/archoto.2010.181.
142. Haigh PI, Urbach DR, Rotstein LE. Extent of thyroidectomy is not a major determinant of survival in lowor high-risk papillary thyroid cancer. Ann Surg Oncol. 2005;12(5):81-89. doi: 10.1007/s10434-004-1165-1.
143. Nixon IJ, Ganly I, Patel SG, et al. Thyroid lobectomy for treatment of well differentiated intrathyroid malignancy. Surgery. 2012;151(4):571-579. doi: 10.1016/j.surg.2011.08.016.
144. Adam MA, Pura J, Gu L, et al. Extent of surgery for papillary thyroid cancer is not associated with survival: an analysis of 61,775 patients. Ann Surg. 2014;260(4):601-605. doi: 10.1097/SLA.0000000000000925.
145. Jonklaas J, Sarlis NJ, Litofsky D, et al. Outcomes of patients with differentiated thyroid carcinoma following initial therapy. Thyroid. 2006;16(12):1229-1242. doi: 10.1089/thy.2006.16.1229.
146. McGriff NJ, Csako G, Gourgiotis L, et al. Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer. Ann Med. 2002;34(7-8):554-564. doi: 10.1080/078538902321117760.
147. Diessl S, Holzberger B, Mader U, et al. Impact of moderate vs stringent TSH suppression on survival in advanced differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 2012;76(4):586-592. doi: 10.1111/j.1365-2265.2011.04272.x.
148. Biondi B, Cooper DS. Benefits of thyrotropin suppression versus the risks of adverse effects in differentiated thyroid cancer. Thyroid. 2010;20(2):135-146. doi: 10.1089/thy.2009.0311.
149. Sugitani I, Fujimoto Y. Effect of postoperative thyrotropin suppressive therapy on bone mineral density in patients with papillary thyroid carcinoma: a prospective controlled study. Surgery. 2011;150(6):1250-1257. doi: 10.1016/j.surg.2011.09.013.
150. Hovens GC, Stokkel MP, Kievit J, et al. Associations of serum thyrotropin concentrations with recurrence and death in differentiated thyroid cancer. J Clin Endocrinol Metab. 2007;92(7):2610-2615. doi: 10.1210/jc.2006-2566.
151. Sawin CT, Geller A, Wolf PA, et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med. 1994;331(19):1249-1252. doi: 10.1056/NEJM199411103311901.
152. Ebina A, Sugitani I, Fujimoto Y, et al. Risk-adapted management of papillary thyroid carcinoma according to our own risk group classification system: is thyroid lobectomy the treatment of choice for low-risk patients? Surgery. 2014;156(6):1579-1588. doi: 10.1016/j.surg.2014.08.060.
153. Frasoldati A, Pesenti M, Gallo M, et al. Diagnosis of neck recurrences in patients with differentiated thyroid carcinoma. Cancer. 2003;97(1):90-96. doi: 10.1002/cncr.1103.
154. Spencer CA, Bergoglio LM, Kazarosyan M, et al. Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas. J Clin Endocrinol Metab. 2005;90(10):5566-5575. doi: 10.1210/jc.2005-0671.
155. Schlumberger M, Berg G, Cohen O, et al. Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective. Eur J Endocrinol. 2004;150(2):105-112. doi: 10.1530/eje.0.1500105.
156. Castagna MG, Brilli L, Pilli T, et al. Limited value of repeat recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin testing in differentiated thyroid carcinoma patients with previous negative rhTSHstimulated thyroglobulin and undetectable basal serum thyroglobulin levels. J Clin Endocrinol Metab.2008;93(1):76-81. doi: 10.1210/jc.2007-1404.
157. Kloos RT, Mazzaferri EL. A single recombinant human thyrotropin-stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later. J Clin Endocrinol Metab. 2005;90(9):5047-5057. doi: 10.1210/jc.2005-0492.
158. Han JM, Kim WB, Yim JH, et al. Long-term clinical outcome of differentiated thyroid cancer patients with undetectable stimulated thyroglobulin level one year after initial treatment. Thyroid. 2012;22(8):784-790. doi: 10.1089/thy.2011.0322.
159. Klubo-Gwiezdzinska J, Burman KD, Van Nostrand D, et al. Does an undetectable rhTSH-stimulated Tg level 12 months after initial treatment of thyroid cancer indicate remission? Clin Endocrinol (Oxf). 2011;74(1):111-117. doi: 10.1111/j.1365-2265.2010.03898.x.
160. Nascimento C, Borget I, Al Ghuzlan A, et al. Persistent disease and recurrence in differentiated thyroid cancer patients with undetectable postoperative stimulated thyroglobulin level. Endocr Relat Cancer. 2011;18(2):R29-40. doi: 10.1677/ERC-10-0292.
161. Verburg FA, Luster M, Cupini C, et al. Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement. Thyroid. 2013;23(10):1211-1225. doi: 10.1089/thy.2012.0606.
162. Castagna MG, Tala Jury HP, Cipri C, et al. The use of ultrasensitive thyroglobulin assays reduces but does not abolish the need for TSH stimulation in patients with differentiated thyroid carcinoma. J Endocrinol Invest. 2011;34(8):e219-223. doi: 10.3275/7571.
163. Baudin E, Do Cao C, Cailleux AF, et al. Positive predictive value of serum thyroglobulin levels, measured during the first year of follow-up after thyroid hormone withdrawal, in thyroid cancer patients. J Clin Endocrinol Metab. 2003;88(3):1107-1111. doi: 10.1210/jc.2002-021365.
164. Pineda JD, Lee T, Ain K, et al. Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan. J Clin Endocrinol Metab. 1995;80(5):1488-1492. doi: 10.1210/jcem.80.5.7744991.
165. Alzahrani AS, Mohamed G, Al Shammary A, et al. Long-term course and predictive factors of elevated serum thyroglobulin and negative diagnostic radioiodine whole body scan in differentiated thyroid cancer. J Endocrinol Invest. 2005;28(6):540-546.
166. Valadao MM, Rosario PW, Borges MA, et al. Pоsitive predictive value of detectable stimulated tg during the first year after therapy of thyroid cancer and the value of comparison with Tg-ablation and Tg measured after 24 months. Thyroid. 2006;16(11):1145-1149. doi: 10.1089/thy.2006.16.1145.
167. Miyauchi A, Kudo T, Miya A, et al. Prognostic impact of serum thyroglobulin doubling-time under thyrotropin suppression in patients with papillary thyroid carcinoma who underwent total thyroidectomy. Thyroid. 2011;21(7):707-716. doi: 10.1089/thy.2010.0355.
168. Wong H, Wong KP, Yau T, et al. Is there a role for unstimulated thyroglobulin velocity in predicting recurrence in papillary thyroid carcinoma patients with detectable thyroglobulin after radioiodine ablation? Ann Surg Oncol. 2012;19(11):3479-3485. doi: 10.1245/s10434-012-2391-6.
169. Padovani RP, Robenshtok E, Brokhin M, et al. Even without additional therapy, serum thyroglobulin concentrations often decline for years after total thyroidectomy and radioactive remnant ablation in patients with differentiated thyroid cancer. Thyroid. 2012;22(8):778-783. doi: 10.1089/thy.2011.0522.
170. Diaz-Soto G, Puig-Domingo M, Martinez-Pino I, et al. Do thyroid cancer patients with basal undetectable Tg measured by current immunoassays require rhTSH testing? Exp Clin Endocrinol Diabetes. 2011;119(6):348-352. doi: 10.1055/s-0030-1269881.
171. Schlumberger M, Hitzel A, Toubert ME, et al. Comparison of seven serum thyroglobulin assays in the follow-up of papillary and follicular thyroid cancer patients. J Clin Endocrinol Metab. 2007;92(7):2487-2495. doi: 10.1210/jc.2006-0723.
172. Spencer CA. Clinical review: Clinical utility of thyroglobulin antibody (TgAb) measurements for patients with differentiated thyroid cancers (DTC). J Clin Endocrinol Metab. 2011;96(12):3615-3627. doi: 10.1210/jc.2011-1740.
173. Taylor KP, Parkington D, Bradbury S, et al. Concordance between thyroglobulin antibody assays. Ann Clin Biochem. 2011;48(Pt 4):367-369. doi: 10.1258/acb.2011.010248.
174. Giovanella L, Keller F, Ceriani L, et al. Heterophile antibodies may falsely increase or decrease thyroglobulin measurement in patients with differentiated thyroid carcinoma. Clin Chem Lab Med. 2009;47(8):952-954. doi: 10.1515/CCLM.2009.230.
175. Verburg FA, Waschle K, Reiners C, et al. Heterophile antibodies rarely influence the measurement of thyroglobulin and thyroglobulin antibodies in differentiated thyroid cancer patients. Horm Metab Res. 2010;42(10):736-739. doi: 10.1055/s-0030-1254132.
176. Latrofa F, Ricci D, Montanelli L, et al. Lymphocytic thyroiditis on histology correlates with serum thyroglobulin autoantibodies in patients with papillary thyroid carcinoma: impact on detection of serum thyroglobulin. J Clin Endocrinol Metab. 2012;97(7):2380-2387. doi: 10.1210/jc.2011-2812.
177. Giovanella L, Ceriani L. Comparison of thyroglobulin antibody interference in first- and second generation thyroglobulin immunoassays. Clin Chem Lab Med. 2011;49(6):1025-1027. doi: 10.1515/CCLM.2011.155.
178. Stanojevic M, Savin S, Cvejic D, et al. Comparison of the influence of thyroglobulin antibodies on serum thyroglobulin values from two different immunoassays in post surgical differentiated thyroid carcinoma patients. J Clin Lab Anal. 2009;23(5):341-346. doi: 10.1002/jcla.20339.
179. Stanojevic M, Savin S, Cvejic D, et al. Correlation of thyroglobulin concentrations measured by radioimmunoassay and immunoradiometric assay and the influence of thyroglobulin antibody. J Immunoassay Immunochem. 2009;30(2):197-207. doi: 10.1080/15321810902782897.
180. Eustatia-Rutten CF, Smit JW, Romijn JA, et al. Diagnostic value of serum thyroglobulin measurements in the follow-up of differentiated thyroid carcinoma, a structured meta-analysis. Clin Endocrinol (Oxf). 2004;61(1):61-74. doi: 10.1111/j.1365-2265.2004.02060.x.
181. Bachelot A, Leboulleux S, Baudin E, et al. Neck recurrence from thyroid carcinoma: serum thyroglobulin and highdose total body scan are not reliable criteria for cure after radioiodine treatment. Clin Endocrinol (Oxf). 2005;62(3):376-379. doi: 10.1111/j.1365-2265.2005.02228.x.
182. Cherk MH, Francis P, Topliss DJ, et al. Incidence and implications of negative serum thyroglobulin but positive I-131 whole-body scans in patients with well-differentiated thyroid cancer prepared with rhTSH or thyroid hormone withdrawal. Clin Endocrinol (Oxf). 2012;76(5):734-740. doi: 10.1111/j.1365-2265.2011.04278.x.
183. Pacini F, Agate L, Elisei R, et al. Outcome of differentiated thyroid cancer with detectable serum Tg and negative diagnostic (131)I whole body scan: comparison of patients treated with high (131)I activities versus untreated patients. J Clin Endocrinol Metab. 2001;86(9):4092-4097. doi: 10.1210/jcem.86.9.7831.
184. Torlontano M, Crocetti U, Augello G, et al. Comparative evaluation of recombinant human thyrotropin-stimulated thyroglobulin levels, 131I wholebody scintigraphy, and neck ultrasonography in the follow-up of patients with papillary thyroid microcarcinoma who have not undergone radioiodine therapy. J Clin Endocrinol Metab. 2006;91(1):60-63. doi: 10.1210/jc.2005-1185.
185. Robbins RJ, Srivastava S, Shaha A, et al. Factors influencing the basal and recombinant human thyrotropin-stimulated serum thyroglobulin in patients with metastatic thyroid carcinoma. J Clin Endocrinol Metab. 2004;89(12):6010-6016. doi: 10.1210/jc.2003-031573.
186. Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 2003;88(4):1433-1441. doi: 10.1210/jc.2002-021702.
187. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489-499. doi: 10.1210/jcem.87.2.8182.
188. Spencer CA 2004 Challenges of serum thyroglobulin (Tg) measurement in the presence of Tg autoantibodies. J Clin Endocrinol Metab. 2004;89(8):3702-3704. doi: 10.1210/jc.2004-0986.
189. Bachelot A, Cailleux AF, Klain M, et al. Relationship between tumor burden and serum thyroglobulin level in patients with papillary and follicular thyroid carcinoma. Thyroid. 2002;12(8):707-711. doi: 10.1089/105072502760258686.
190. Spencer C, Fatemi S. Thyroglobulin antibody (TgAb) methods – strengths, pitfalls and clinical utility for monitoring TgAb-positive patients with differentiated thyroid cancer. Best Pract Res Clin Endocrinol Metab. 2013;27(5):701-712. doi: 10.1016/j.beem.2013.07.003.
191. Nygaard B, Bentzen J, Laurberg P, et al. Large discrepancy in the results of sensitive measurements of thyroglobulin antibodies in the follow-up on thyroid cancer: a diagnostic dilemma. Eur Thyroid J. 2012;1(3):193-197. doi: 10.1159/000341362.
192. Hoofnagle AN, Becker JO, Wener MH, et al. Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry. Clin Chem. 2008;54(11):1796-1804. doi: 10.1373/clinchem.2008.109652.
193. Clarke NJ, Zhang Y, Reitz RE. A novel mass spectrometry-based assay for the accurate measurement of thyroglobulin from patient samples containing antithyroglobulin autoantibodies. J Investig Med. 2012;60(8):1157-1163. doi: 10.2310/JIM.0b013e318276deb4.
194. Kushnir MM, Rockwood AL, Roberts WL, et al. Measurement of thyroglobulin by liquid chromatography-tandem mass spectrometry in serum and plasma in the presence of antithyroglobulin autoantibodies. Clin Chem. 2013;59(6):982-990. doi: 10.1373/clinchem.2012.195594.
195. Hoofnagle AN, Roth MY. Clinical review: improving the measurement of serum thyroglobulin with mass spectrometry. J Clin Endocrinol Metab. 2013;98(4):1343-1352. doi: 10.1210/jc.2012-4172.
196. Snozek CL, Chambers EP, Reading CC, et al. Serum thyroglobulin, high-resolution ultrasound, and lymph node thyroglobulin in diagnosis of differentiated thyroid carcinoma nodal metastases. J Clin Endocrinol Metab. 2007;92(11):4278-4281. doi: 10.1210/jc.2007-1075.
197. Boi F, Baghino G, Atzeni F, et al. The diagnostic value for differentiated thyroid carcinoma metastases of thyroglobulin (Tg) measurement in washout fluid from fine-needle aspiration biopsy of neck lymph nodes is maintained in the presence of circulating anti-Tg antibodies. J Clin Endocrinol Metab.2006;91(4):1364-1369. doi: 10.1210/jc.2005-1705.
198. Grani G, Fumarola A. Thyroglobulin in lymph node fine-needle aspiration wash-out: a systematic review and meta-analysis of diagnostic accuracy. J Clin Endocrinol Metab. 2014;99(6):1970-1982. doi: 10.1210/jc.2014-1098.
199. Pacini F, Fugazzola L, Lippi F, et al. Detection of thyroglobulin in fine needle aspirates of nonthyroidal neck masses: a clue to the diagnosis of metastatic differentiated thyroid cancer. J Clin Endocrinol Metab. 1992;74(6):1401-1404. doi: 10.1210/jcem.74.6.1592886.
200. Spencer C, Fatemi S, Singer P, et al. Serum basal thyroglobulin measured by a second generation assay correlates with the recombinant human thyrotropin-stimulated thyroglobulin response in patients treated for differentiated thyroid cancer. Thyroid. 2010;20(6):587-595. doi: 10.1089/thy.2009.0338.
201. Pacini F, Molinaro E, Castagna MG, et al. Recombinant human thyrotropin-stimulated serum thyroglobulin combined with neck ultrasonography has the highest sensitivity in monitoring differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2003;88(8):3668-3673. doi: 10.1210/jc.2002-021925.
202. Torres MR, Nobrega Neto SH, Rosas RJ, et al. Thyroglobulin in the washout fluid of lymph-node biopsy: what is its role in the follow-up of differentiated thyroid carcinoma? Thyroid. 2014;24(1):7-18. doi: 10.1089/thy.2013.0244.
203. Frasoldati A, Toschi E, Zini M, et al. Role of thyroglobulin measurement in fine-needle aspiration biopsies of cervical lymph nodes in patients with differentiated thyroid cancer. Thyroid. 1999;9:105-111. doi: 10.1089/thy.1999.9.105.
204. Baloch ZW, Barroeta JE, Walsh J, et al. Utility of thyroglobulin measurement in fine-needle aspiration biopsy specimens of lymph nodes in the diagnosis of recurrent thyroid carcinoma. Cytojournal. 2008;5:1. doi: 10.1186/1742-6413-5-1.
205. Avram AM, Fig LM, Frey KA, et al. Preablation 131-I scans with SPECT/CT in postoperative thyroid cancer patients: what is the impact on staging? J Clin Endocrinol Metab. 2013;98(3):1163-1171. doi: 10.1210/jc.2012-3630.
206. Sherman SI, Tielens ET, Sostre S, et al. Clinical utility of posttreatment radioiodine scans in the management of patients with thyroid carcinoma. J Clin Endocrinol Metab. 1994;78(3):629-634. doi: 10.1210/jcem.78.3.8126134.
207. Fatourechi V, Hay ID, Mullan BP, et al. Are posttherapy radioiodine scans informative and do they influence subsequent therapy of patients with differentiated thyroid cancer? Thyroid. 2000;10(7):573-577. doi: 10.1089/thy.2000.10.573.
208. Souza Rosario PW, Barroso AL, Rezende LL, et al. Post I-131 therapy scanning in patients with thyroid carcinoma metastases: an unnecessary cost or a relevant contribution? Clin Nucl Med. 2004;29(12):795-798.
209. Spies WG, Wojtowicz CH, Spies SM, et al. Value of post-therapy whole-body I-131 imaging in the evaluation of patients with thyroid carcinoma having undergone high-dose I-131 therapy. Clin Nucl Med. 1989;14(11):793-800.
210. Ciappuccini R, Heutte N, Trzepla G, et al. Postablation (131)I scintigraphy with neck and thorax SPECT-CT and stimulated serum thyroglobulin level predict the outcome of patients with differentiated thyroid cancer. Eur J Endocrinol. 2011;164(6):961-969. doi: 10.1530/EJE-11-0156.
211. Salvatori M, Perotti G, Villani MF, et al. Determining the appropriate time of execution of an I-131 post-therapy whole-body scan: comparison between early and late imaging. Nucl Med Commun. 2013;34(9):900-908. doi: 10.1097/MNM.0b013e328363cc5c.
212. Kohlfuerst S, Igerc I, Lobnig M, et al. Posttherapeutic (131)I SPECTCT offers high diagnostic accuracy when the findings on conventional planar imaging are inconclusive and allows a tailored patient treatment regimen. Eur J Nucl Med Mol Imaging. 2009;36(6):886-893. doi: 10.1007/s00259-008-1044-2.
213. Chen L, Luo Q, Shen Y, et al. Incremental value of 131I SPECT/CT in the management of patients with differentiated thyroid carcinoma. J Nucl Med. 2008;49(12):1952-1957. doi: 10.2967/jnumed.108.052399.
214. Schmidt D, Linke R, Uder M, et al. Five months’ follow-up of patients with and without iodinepositive lymph node metastases of thyroid carcinoma as disclosed by (131)I-SPECT/CT at the first radioablation Eur J Nucl Med Mol Imaging. 2010;37(4):699-705. doi: 10.1007/s00259-009-1299-2.
215. Maruoka Y, Abe K, Baba S, et al. Incremental diagnostic value of SPECT/CT with 131I scintigraphy after radioiodine therapy in patients with well-differentiated thyroid carcinoma. Radiology. 2012;265(3):902-909. doi: 10.1148/radiol.12112108.
216. Grewal RK, Tuttle RM, Fox J, et al. The effect of posttherapy 131I SPECT/CT on risk classification and management of patients with differentiated thyroid cancer. J Nucl Med. 2010;51(9):1361-1367. doi: 10.2967/jnumed.110.075960.
217. Padovani RP, Kasamatsu TS, Nakabashi CC, et al. One month is sufficient for urinary iodine to return to its baseline value after the use of water-soluble iodinated contrast agents in postthyroidectomy patients requiring radioiodine therapy. Thyroid. 2012;22(9):926-930. doi: 10.1089/thy.2012.0099.
218. Leboulleux S, Schroeder PR, Schlumberger M, et al. The role of PET in follow-up of patients treated for differentiated epithelial thyroid cancers. Nat Clin Pract Endocrinol Metab. 2007;3(2):112-121. doi: 10.1038/ncpendmet0402.
219. Robbins RJ, Wan Q, Grewal RK, et al. Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning. J Clin Endocrinol Metab. 2006;91(2):498-505. doi: 10.1210/jc.2005-1534.
220. Deandreis D, Al Ghuzlan A, Leboulleux S, et al. Do histological, immunohistochemical, and metabolic (radioiodine and fluorodeoxyglucose uptakes) patterns of metastatic thyroid cancer correlate with patient outcome? Endocr Relat Cancer. 2011;18(1):159-169. doi: 10.1677/ERC-10-0233.
221. Leboulleux S, Schroeder PR, Busaidy NL, et al. Assessment of the incremental value of recombinant thyrotropin stimulation before 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography imaging to localize residual differentiated thyroid cancer. J Clin Endocrinol Metab.2009;94(4):1310-1316. doi: 10.1210/jc.2008-1747.
222. Takashima S, Sone S, Takayama F, et al. Papillary thyroid carcinoma: MR diagnosis of lymph node metastasis. AJNR Am J Neuroradiol. 1998;19(3):509-513.
223. Gross ND, Weissman JL, Talbot JM, et al. MRI detection of cervical metastasis from differentiated thyroid carcinoma. Laryngoscope. 2001;111(11 Pt 1):1905-1909. doi: 10.1097/00005537-200111000-00006.
224. Toubert ME, Cyna-Gorse F, Zagdanski AM, et al. Cervicomediastinal magnetic resonance imaging in persistent or recurrent papillary thyroid carcinoma: clinical use and limits. Thyroid. 1999;9(6):591-597. doi: 10.1089/thy.1999.9.591.
225. Wang JC, Takashima S, Takayama F, et al. Tracheal invasion by thyroid carcinoma: prediction using MR imaging. AJR Am J Roentgenol. 2001;177(4):929-936.
226. Wang J, Takashima S, Matsushita T, et al. Esophageal invasion by thyroid carcinomas: prediction using magnetic resonance imaging. J Comput Assist Tomogr. 2003;27(1):18-25. doi: 10.1097/00004728-200301000-00004.
227. Lee DH, Kang WJ, Seo HS, et al. Detection of metastatic cervical lymph nodes in recurrent papillary thyroid carcinoma: computed tomography versus positron emission tomography-computed tomography. J Comput Assist Tomogr. 2009;33(5):805-810. doi: 10.1097/RCT.0b013e31818fb3f1.
228. Rosario PW, Mourao GF, dos Santos JB, et al. Is empirical radioactive iodine therapy still a valid approach to patients with thyroid cancer and elevated thyroglobulin? Thyroid. 2014;24(3):533-536. doi: 10.1089/thy.2013.0427.
229. Brose MS, Nutting CM, Jarzab B, et al. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Lancet. 2014;384(9940):319-328. doi: 10.1016/S0140-6736(14)60421-9.
230. Anderson RT, Linnehan JE, Tongbram V, et al. Clinical, safety, and economic evidence in radioactive iodine-refractory differentiated thyroid cancer: a systematic literature review. Thyroid. 2013;23(4):392-407. doi: 10.1089/thy.2012.0520.
231. Leboulleux S, Bastholt L, Krause T, et al. Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial. Lancet Oncol. 2012;13(9):897-905. doi: 10.1016/S1470-2045(12)70335-2.
232. Schlumberger M, Tahara M, Wirth LJ, et al. Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med. 2015;372:621-630. doi: 10.1056/NEJMoa1406470.
233. Cohen EE, Rosen LS, Vokes EE, et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol. 2008;26(29):4708-4713. doi: 10.1200/JCO.2007.
234. Bible KC, Suman VJ, Molina JR, et al. Efficacy of pazopanib in progressive, radioiodinerefractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study. Lancet Oncol. 2010;11(10):962-972. doi: 10.1016/S1470-2045(10)70203-5.
235. Carr LL, Mankoff DA, Goulart BH, et al. Phase II study of daily sunitinib in FDG-PET-positive, iodinerefractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res. 2010;16(21):5260-5268. doi: 10.1158/1078-0432.
236. Droz JP, Schlumberger M, Rougier P, et al. Chemotherapy in metastatic nonanaplastic thyroid cancer: experience at the Institut Gustave-Roussy. Tumori. 1990;76(5):480-483.
237. Schutz FA, Je Y, Richards CJ, et al. Metaanalysis of randomized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors. J Clin Oncol. 2012;30(8):871-877. doi: 10.1200/JCO.2011.37.1195.
238. Loh JA, Wartofsky L, Jonklaas J, et al. The magnitude of increased levothyroxine requirements in hypothyroid pregnant women depends upon the etiology of the hypothyroidism. Thyroid. 2009;19(3):269-275. doi: 10.1089/thy.2008.0413.
239. Pacini F, Schlumberger M, Dralle H, et al. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol. 2006;154(6):787-803. doi: 10.1530/eje.1.02158.
240. Sawka AM, Lakra DC, Lea J, et al. A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors. Clin Endocrinol (Oxf). 2008;69(3):479-490. doi: 10.1111/j.1365-2265.2008.03222.x.
241. Garsi JP, Schlumberger M, Rubino C, et al. Therapeutic administration of 131I for differentiated thyroid cancer: radiation dose to ovaries and outcome of pregnancies. J Nucl Med. 2008;49(5):845-852. doi: 10.2967/jnumed.107.046599.
242. Pacini F, Gasperi M, Fugazzola L, et al. Testicular function in patients with differentiated thyroid carcinoma treated with radioiodine. J Nucl Med. 1994;35(9):1418-1422.
Review
For citations:
Beltsevich D.G., Vanushko V.E., Rumiantsev P.O., Melnichenko G.A., Kuznetsov N.S., Abrosimov A.Yu., Polyakov V.G., Mudunov A.M., Podvyaznikov S.O., Romanov I.S., Polyakov A.P., Sleptsov I.V., Chernikov R.A., Vorobyov S.L., Fadeyev V.V. 2017 Russian clinical practice guidelines for differentiated thyroid cancer diagnosis and treatment. Endocrine Surgery. 2017;11(1):6-27. (In Russ.) https://doi.org/10.14341/serg201716-27

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