Topical diagnostic methods in ACTH-producing neuroendocrine tumors with various localization. Topical diagnostic of ACTH-producing neuroendocrine tumors is a major stage in management of patients with ACTH-producing syndrome, because one of the main methods of treatment of such patients is surgical. There are several methods of topical diagnostic of ACTH-producing tumors with ectopic ocalization which have some advantages and disadvantages. At the same time until now any of existing methods of research doesn't guarantee 100% result that leads to obtaining the false positive conclusions and, as a result, carrying out unreasonable surgical operation. This report is about the main methods of topical diagnosis and their comparative characteristics. Besides possible ways to increase sensitivity and efficiency of methods and improve results are discussed in article.

Results of various surgical techniques application in primary hyperparathyroidism patients were studied. Bilateral neck exploration, unilateral neck exploration, selective parathyroidectomy (conventional and videoassisted) were used in 297 patients with primary hyperparathyroidism. Results of the study showed high efficacy of selective parathyroidectomy with some benefits in comparison with bilateral neck exploration (reduced postoperative pain, better cosmetic result, diminished hospital stay etc.).

Contemporary development of two hormonal active tumors in different layers of one adrenal gland is occurring extremely rarely in clinical practice. Authors adduce their own clinical cases of competitive adrenal tumors.

Ectopic hormone-secreting pheochromocytomas are rare. Only case reports exist in the literature. Despite the large number of guides on diagnosis and treatment of pheochromocytoma, and Cushing syndrome, the extreme rarity of ectopic ACTH-syndrome caused by pheochromocytoma, and complexity of clinical cause numerous diagnostic errors leading to treatment failure. Therefore, we belive it appropriate to share our experience of this group of patients.